Gene
grk5
- ID
- ZDB-GENE-091204-274
- Name
- G protein-coupled receptor kinase 5
- Symbol
- grk5 Nomenclature History
- Previous Names
-
- si:dkey-171l20.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity. Acts upstream of or within heart development; positive regulation of Wnt signaling pathway; and regulation of heart contraction. Predicted to be active in cytoplasm. Is expressed in brain; cardiovascular system; and otic vesicle.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-grk5 | N/A | (3) |
| MO2-grk5 | N/A | Chen et al., 2009 |
| MO3-grk5 | N/A | Philipp et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | GPCR kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 2 | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A9JRC5 | InterPro | 440 | |||||||||
| UniProtKB:A0A8M9QKR0 | InterPro | 529 | |||||||||
| UniProtKB:F1RAR9 | InterPro | 588 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-171B11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-171L20 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001173503 (1) | 2460 nt | ||
| Genomic | GenBank:CT027796 (1) | 87354 nt | ||
| Polypeptide | UniProtKB:F1RAR9 (1) | 588 aa |
No data available
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Zhao, Z., Lee, R.T., Pusapati, G.V., Iyu, A., Rohatgi, R., Ingham, P.W. (2016) An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. EMBO reports. 17(5):739-52
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Philipp, M., Berger, I.M., Just, S., Caron, M.G. (2014) Overlapping and Opposing Functions of GRK2 and GRK5 during Heart Development. The Journal of biological chemistry. 289(38):26119-30
- Burkhalter, M.D., Fralish, G.B., Premont, R.T., Caron, M.G., and Philipp, M. (2013) Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking. Cell Reports. 4(4):625-632
- Chen, M., Philipp, M., Wang, J., Premont, R.T., Garrison, T.R., Caron, M.G., Lefkowitz, R.J., and Chen, W. (2009) G protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. The Journal of biological chemistry. 284(50):35040-35048
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