Gene
antxr1b
- ID
- ZDB-GENE-091204-21
- Name
- ANTXR cell adhesion molecule 1b
- Symbol
- antxr1b Nomenclature History
- Previous Names
-
- si:dkey-261l11.3
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane signaling receptor activity. Predicted to be located in filopodium membrane and lamellipodium membrane. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in GAPO syndrome and colorectal carcinoma. Orthologous to human ANTXR1 (ANTXR cell adhesion molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| GAPO syndrome | Alliance | GAPO syndrome | 230740 |
| {?Hemangioma, capillary infantile, susceptibility to} | 602089 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Anthrax toxin receptor, C-terminal | Anthrax toxin receptor, extracellular domain | von Willebrand factor A-like domain superfamily | von Willebrand factor, type A |
|---|---|---|---|---|---|---|
| UniProtKB:A0A286YBD3 | InterPro | 607 | ||||
| UniProtKB:A0AB32U207 | InterPro | 645 | ||||
| UniProtKB:A0AB32U2Z6 | InterPro | 502 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
antxr1b-201
(1)
|
Ensembl | 2,609 nt | ||
| mRNA |
antxr1b-202
(1)
|
Ensembl | 2,244 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-261L11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068224030 (1) | 4949 nt | ||
| Genomic | GenBank:CU571179 (1) | 151825 nt | ||
| Polypeptide | UniProtKB:A0AB32U207 (1) | 645 aa |
- Bürgi, J., Abrami, L., Castanon, I., Abriata, L.A., Kunz, B., Yan, S.E., Lera, M., Unger, S., Superti-Furga, A., Peraro, M.D., Gaitan, M.G., van der Goot, F.G. (2020) Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis. Developmental Cell. 53:418-430.e4
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Castanon, I., Abrami, L., Holtzer, L., Heisenberg, C.P., van der Goot, F.G., and González-Gaitán, M. (2013) Anthrax toxin receptor 2a controls mitotic spindle positioning. Nature cell biology. 15(1):28-39
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