Gene
glis2b
- ID
- ZDB-GENE-091204-120
- Name
- GLIS family zinc finger 2b
- Symbol
- glis2b Nomenclature History
- Previous Names
-
- si:rp71-84k24.2
- znphp7.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cilium movement and morphogenesis of an epithelium. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in nucleus. Is expressed in eye; gut; heart; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kim et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-glis2b | N/A | (2) |
MO2-glis2b | N/A | Kim et al., 2013 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
nephronophthisis 7 | Alliance | Nephronophthisis 7 | 611498 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | C2H2-type zinc-finger protein GLI-like | ZIC1-5/GLI1-3like, C2H2 zinc finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
---|---|---|---|---|---|---|
UniProtKB:T1WQU8 | InterPro | 489 | ||||
UniProtKB:A0A0R4IE83 | InterPro | 489 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
glis2b-201
(1)
|
Ensembl | 1,470 nt | ||
mRNA |
glis2b-202
(1)
|
Ensembl | 1,011 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | RP71-84K24 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001289885 (1) | 1470 nt | ||
Genomic | GenBank:CT033841 (1) | 162408 nt | ||
Polypeptide | UniProtKB:A0A0R4IE83 (1) | 489 aa |
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Ramachandran, H., Schäfer, T., Kim, Y., Herfurth, K., Hoff, S., Lienkamp, S.S., Kramer-Zucker, A., and Walz, G. (2014) Interaction with the Bardet-Biedl Gene Product TRIM32/BBS11 Modifies the Half-life and Localization of Glis2/NPHP7. The Journal of biological chemistry. 289(12):8390-8401
- Kim, Y.H., Epting, D., Slanchev, K., Engel, C., Walz, G., and Kramer-Zucker, A. (2013) A Complex of BBS1 and NPHP7 Is Required for Cilia Motility in Zebrafish. PLoS One. 8(9):e72549
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