Gene

gucy2ca

ID

ZDB-GENE-091118-67

Name

guanylate cyclase 2Ca

Symbol

gucy2ca Nomenclature History

Previous Names

gucy2c
si:ch211-163m16.1

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have guanylate cyclase activity; natriuretic peptide receptor activity; and peptide hormone binding activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (guanylate cyclase 2C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Pérez-Rius et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gucy2ca Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital diarrhea 6	Alliance	Diarrhea 6	614616
		Meconium ileus	614665

Associated With gucy2ca Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I
Homologous_superfamily	IPR029787	Nucleotide cyclase

Domain Details Per Protein

Protein	Length	Adenylyl cyclase class-3/4/guanylyl cyclase	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	Nucleotide cyclase	Periplasmic binding protein-like I	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain
UniProtKB:A0A8M3AQ67 InterPro	1025

Transcripts

Genome Browsers: No data available

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gucy2c-202 (1) Ensembl	Havana	1427 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations