Gene
duox
- ID
- ZDB-GENE-091117-14
- Name
- dual oxidase
- Symbol
- duox Nomenclature History
- Previous Names
-
- duox1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; leukocyte chemotaxis; and thyroid hormone generation. Predicted to be located in apical plasma membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; endocrine system; epidermis; eye; and pleuroperitoneal region. Used to study congenital hypothyroidism and hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to several human genes including DUOX2 (dual oxidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thyroid dyshormonogenesis 6 | Alliance | Thyroid dyshormonogenesis 6 | 607200 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR013112 | FAD-binding 8 |
| Domain | IPR013121 | Ferric reductase, NAD binding domain |
| Domain | IPR013130 | Ferric reductase transmembrane component-like domain |
| Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
| Domain | IPR034821 | Dual oxidase, peroxidase domain |
| Family | IPR019791 | Haem peroxidase, animal-type |
| Family | IPR050369 | Respiratory burst oxidase/Ferric reductase |
| Homologous_superfamily | IPR010255 | Haem peroxidase superfamily |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR017938 | Riboflavin synthase-like beta-barrel |
| Homologous_superfamily | IPR037120 | Haem peroxidase domain superfamily, animal type |
| Homologous_superfamily | IPR039261 | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | Dual oxidase, peroxidase domain | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | FAD-binding 8 | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Ferric reductase, NAD binding domain | Ferric reductase transmembrane component-like domain | Haem peroxidase, animal-type | Haem peroxidase domain superfamily, animal type | Haem peroxidase superfamily | Respiratory burst oxidase/Ferric reductase | Riboflavin synthase-like beta-barrel |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YYK2 | InterPro | 1528 | ||||||||||||||
| UniProtKB:A0A8M9PVM3 | InterPro | 1528 | ||||||||||||||
| UniProtKB:A0A8M9P6X2 | InterPro | 1527 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available