ZFIN is now using GRCz12tu for Genomic Data
Gene
duox
- ID
- ZDB-GENE-091117-14
- Name
- dual oxidase
- Symbol
- duox Nomenclature History
- Previous Names
-
- duox1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; leukocyte chemotaxis; and thyroid hormone generation. Predicted to be located in apical plasma membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; endocrine system; epidermis; eye; and pleuroperitoneal region. Used to study congenital hypothyroidism and hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to several human genes including DUOX2 (dual oxidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9892 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13017 | Allele with one point mutation | Exon 23 | Premature Stop | ENU | |
| zf3298 | Allele with one deletion | Exon 21 | Unknown | CRISPR | |
| zf3299 | Allele with one deletion | Exon 21 | Unknown | CRISPR | |
| zf3300 | Allele with one deletion | Exon 21 | Unknown | CRISPR | |
| zf4123 | Allele with one deletion | Exon 5 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thyroid dyshormonogenesis 6 | Alliance | Thyroid dyshormonogenesis 6 | 607200 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dual oxidase, peroxidase domain | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | FAD-binding 8 | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Ferric reductase, NAD binding domain | Ferric reductase transmembrane component-like domain | Haem peroxidase, animal-type | Haem peroxidase domain superfamily, animal type | Haem peroxidase superfamily | Respiratory burst oxidase/Ferric reductase | Riboflavin synthase-like beta-barrel |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YYK2 | InterPro | 1528 | ||||||||||||||
| UniProtKB:A0A8M9PVM3 | InterPro | 1528 | ||||||||||||||
| UniProtKB:A0A8M9P6X2 | InterPro | 1527 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(4xUAS:dnduox,cyraa:Venus) |
|
| 1 | Zebrafish Nomenclature Committee |
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No data available
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_073943293 (1) | GRCz12tu | 5187 nt | |
| Genomic | GenBank:JBMGRA010000025 (1) | |||
| Polypeptide | UniProtKB:A0A8M6YYK2 (1) | 1528 aa |
- Jurgens, J.A., Matos Ruiz, P.M., King, J., Foster, E.E., Berube, L., Chan, W.M., Barry, B.J., Jeong, R., Rothman, E., Whitman, M.C., MacKinnon, S., Rivera-Quiles, C., Pratt, B.M., Easterbrooks, T., Mensching, F.M., Di Gioia, S.A., Pais, L., England, E.M., de Berardinis, T., Magli, A., Koc, F., Asakawa, K., Kawakami, K., O'Donnell-Luria, A., Hunter, D.G., Robson, C.D., Bulyk, M.L., Engle, E.C. (2025) Gene Identification for Ocular Congenital Cranial Motor Neuron Disorders Using Human Sequencing, Zebrafish Screening, and Protein Binding Microarrays. Investigative ophthalmology & visual science. 66:6262
- Leon-Icaza, S.A., Frétaud, M., Cornélie, S., Bureau, C., Yatime, L., Floto, R.A., Renshaw, S.A., Herrmann, J.L., Langevin, C., Cougoule, C., Bernut, A. (2025) Curcumin-mediated NRF2 induction limits inflammatory damage in, preclinical models of cystic fibrosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 186:117957117957
- Chen, A.Q., Xue, M., Qiu, C.Z., Zhang, H.Y., Zhou, R., Zhang, L., Yin, Z.J., Ren, D.L. (2023) Circadian clock1a coordinates neutrophil recruitment via nfe212a/duox-reactive oxygen species pathway in zebrafish. Cell Reports. 42:113179113179
- Chopra, K., Folkmanaitė, M., Stockdale, L., Shathish, V., Ishibashi, S., Bergin, R., Amich, J., Amaya, E. (2023) Duox is the primary NADPH oxidase responsible for ROS production during adult caudal fin regeneration in zebrafish. iScience. 26:106147106147
- Harper, M., Hu, Y., Donahue, J., Acosta, B., Dievenich Braes, F., Nguyen, S., Zeng, J., Barbaro, J., Lee, H., Bui, H., McMenamin, S.K. (2023) Thyroid hormone regulates proximodistal patterning in fin rays. Proceedings of the National Academy of Sciences of the United States of America. 120:e2219770120e2219770120
- Zheng, S.Y., Shao, X., Qi, Z., Yan, M., Tao, M.H., Wu, X.M., Zhang, L., Ma, J., Li, A., Chang, M.X. (2023) Zebrafish nos2a benefits bacterial proliferation via suppressing ROS and inducing NO production to impair the expressions of inflammatory cytokines and antibacterial genes. Fish & shellfish immunology. 142:109178
- Cadiz Diaz, A., Schmidt, N.A., Yamazaki, M., Hsieh, C.J., Lisse, T.S., Rieger, S. (2022) Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2115009119
- Thauvin, M., de Sousa, R.M., Alves, M., Volovitch, M., Vriz, S., Rampon, C. (2022) An early Shh-H2O2 reciprocal regulatory interaction controls the regenerative program during zebrafish fin regeneration. Journal of Cell Science. 135(6):
- Zasu, A., Hishima, F., Thauvin, M., Yoneyama, Y., Kitani, Y., Hakuno, F., Volovitch, M., Takahashi, S.I., Vriz, S., Rampon, C., Kamei, H. (2022) NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in endocrinology. 13:929668
- Guan, R., Wen, X.Y., Leung, C.H., Ciano-Oliveira, C.D., Lam, S., Dai, S.Y., Karbassi, F., Mauro, A., Wang, Y., Rotstein, O. (2021) Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox. PLoS One. 16:e0260442
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