Gene
duox
- ID
- ZDB-GENE-091117-14
- Name
- dual oxidase
- Symbol
- duox Nomenclature History
- Previous Names
-
- duox1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Is predicted to enable superoxide-generating NAD(P)H oxidase activity. Involved in defense response and superoxide anion generation. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; leukocyte migration; and thyroid gland development. Predicted to be located in apical plasma membrane. Predicted to be integral component of membrane. Predicted to be part of NADPH oxidase complex. Is expressed in several structures, including central nervous system; endocrine system; epidermis; eye; and pleuroperitoneal region. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to human DUOX1 (dual oxidase 1) and DUOX2 (dual oxidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
thyroid dyshormonogenesis 6 | Alliance | Thyroid dyshormonogenesis 6 | 607200 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
congenital hypothyroidism | duoxsa13017/sa13017 | standard conditions | Chopra et al., 2019 |
congenital hypothyroidism | duoxsa9892/sa9892 | standard conditions | Chopra et al., 2019 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
Domain | IPR002048 | EF-hand domain |
Domain | IPR013112 | FAD-binding 8 |
Domain | IPR013121 | Ferric reductase, NAD binding domain |
Domain | IPR013130 | Ferric reductase transmembrane component-like domain |
Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
Domain | IPR034821 | Dual oxidase, peroxidase domain |
Family | IPR019791 | Haem peroxidase, animal-type |
Homologous_superfamily | IPR010255 | Haem peroxidase superfamily |
Homologous_superfamily | IPR011992 | EF-hand domain pair |
Homologous_superfamily | IPR017938 | Riboflavin synthase-like beta-barrel |
Homologous_superfamily | IPR037120 | Haem peroxidase domain superfamily, animal type |
Homologous_superfamily | IPR039261 | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain |
Domain Details Per Protein
Protein | Length | Dual oxidase, peroxidase domain | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | FAD-binding 8 | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Ferric reductase, NAD binding domain | Ferric reductase transmembrane component-like domain | Haem peroxidase, animal-type | Haem peroxidase domain superfamily, animal type | Haem peroxidase superfamily | Riboflavin synthase-like beta-barrel |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q08JS2
|
1507 | |||||||||||||
UniProtKB:A0A2R8RLY1
|
1499 | |||||||||||||
UniProtKB:F1QVF2
|
1519 | |||||||||||||
UniProtKB:A0A2R8QJC5
|
450 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available