Gene

atp8b1

ID
ZDB-GENE-091116-14
Name
ATPase phospholipid transporting 8B1
Symbol
atp8b1 Nomenclature History
Previous Names
  • si:ch211-180b7.2
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in Golgi organization and phospholipid translocation. Predicted to localize to Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atp8b1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
benign recurrent intrahepatic cholestasis 1 Alliance Cholestasis, benign recurrent intrahepatic 243300
intrahepatic cholestasis of pregnancy 1 Alliance Cholestasis, intrahepatic, of pregnancy, 1 147480
progressive familial intrahepatic cholestasis 1 Alliance Cholestasis, progressive familial intrahepatic 1 211600
Associated With atp8b1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR032630 P-type ATPase, C-terminal
Domain IPR032631 P-type ATPase, N-terminal
Domain IPR044492 P-type ATPase, haloacid dehalogenase domain
Family IPR001757 P-type ATPase
Family IPR006539 P-type ATPase, subfamily IV
Family IPR030346 Phospholipid-transporting ATPase IC
Homologous_superfamily IPR008250 P-type ATPase, A domain superfamily
Homologous_superfamily IPR023214 HAD superfamily
Homologous_superfamily IPR023298 P-type ATPase, transmembrane domain superfamily
Homologous_superfamily IPR023299 P-type ATPase, cytoplasmic domain N
Homologous_superfamily IPR036412 HAD-like superfamily
PTM IPR018303 P-type ATPase, phosphorylation site
Domain Details Per Protein
Protein Length HAD-like superfamily HAD superfamily Phospholipid-transporting ATPase IC P-type ATPase P-type ATPase, A domain superfamily P-type ATPase, C-terminal P-type ATPase, cytoplasmic domain N P-type ATPase, haloacid dehalogenase domain P-type ATPase, N-terminal P-type ATPase, phosphorylation site P-type ATPase, subfamily IV P-type ATPase, transmembrane domain superfamily
UniProtKB:E7FFK0 1249
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations