Gene
dnah3
- ID
- ZDB-GENE-091112-7
- Name
- dynein axonemal heavy chain 3
- Symbol
- dnah3 Nomenclature History
- Previous Names
-
- si:dkey-161j23.4
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and dynein intermediate chain binding activity. Predicted to be involved in cilium movement. Predicted to act upstream of or within microtubule-based movement. Predicted to be located in cytoplasm; microtubule; and motile cilium. Predicted to be part of axonemal dynein complex. Orthologous to human DNAH3 (dynein axonemal heavy chain 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yamaguchi et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
gyf31 | Allele with one deletion | Unknown | Unknown | CRISPR | |
sa8865 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa24559 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa31104 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa37960 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa44192 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa44193 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa44194 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa45015 | Allele with one point mutation | Unknown | Unknown | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-dnah3 | Wang et al., 2021 | |
CRISPR2-dnah3 | Wang et al., 2021 | |
CRISPR3-dnah3 | Wang et al., 2021 | |
CRISPR4-dnah3 | Wang et al., 2021 | |
CRISPR5-dnah3 | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | AAA+ ATPase domain | Dynein heavy chain | Dynein heavy chain 3, AAA+ lid domain | Dynein heavy chain, AAA1 domain, small subdomain | Dynein heavy chain, AAA 5 extension domain | Dynein heavy chain AAA lid domain | Dynein heavy chain AAA lid domain superfamily | Dynein heavy chain, AAA module D4 | Dynein heavy chain, ATP-binding dynein motor region | Dynein heavy chain, coiled coil stalk | Dynein heavy chain, C-terminal domain | Dynein heavy chain, C-terminal domain, barrel region | Dynein heavy chain, domain 2, N-terminal | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | Dynein heavy chain, linker | Dynein heavy chain, linker, subdomain 3 | Dynein heavy chain region D6 P-loop domain | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3ANU1 | InterPro | 4007 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-40F10 | ZFIN Curated Data | |
Contained in | BAC | DKEY-161J23 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068217263 (1) | 15484 nt | ||
Genomic | GenBank:BX547934 (1) | 173532 nt | ||
Polypeptide | UniProtKB:A0A8M3ANU1 (1) | 4007 aa |
- Comparative Orthology
- Alliance
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Wang, Y., Troutwine, B.R., Zhang, H., Gray, R.S. (2021) The axonemal dynein heavy chain 10 gene is essential for monocilia motility and spine alignment in zebrafish. Developmental Biology. 482:82-90
- Yamaguchi, H., Oda, T., Kikkawa, M., Takeda, H. (2018) Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly. eLIFE. 7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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