Gene
grb10b
- ID
- ZDB-GENE-091020-12
- Name
- growth factor receptor-bound protein 10b
- Symbol
- grb10b Nomenclature History
- Previous Names
-
- si:ch211-149m3.3
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable insulin receptor binding activity. Predicted to be involved in insulin receptor signaling pathway; negative regulation of Wnt signaling pathway; and negative regulation of insulin receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm. Orthologous to human GRB10 (growth factor receptor bound protein 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17433 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18384 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19132 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22754 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22755 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36043 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42660 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42661 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | APBB1IP, PH domain | BPS (Between PH and SH2) domain | Grb10, SH2 | GRB/APBB1IP | PH-like domain superfamily | Pleckstrin homology domain | Ras-associating domain | SH2 domain | SH2 domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B462 | InterPro | 444 | ||||||||||
| UniProtKB:F1QSC3 | InterPro | 594 | ||||||||||
| UniProtKB:A0A8M9P869 | InterPro | 595 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grb10b-201
(1)
|
Ensembl | 5,586 nt | ||
| ncRNA |
grb10b-002
(1)
|
Ensembl | 1,382 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-149M3 | ||
| Contained in | BAC | CH211-207G17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-266G24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068214086 (1) | 5111 nt | ||
| Genomic | GenBank:BX537113 (1) | 206307 nt | ||
| Polypeptide | UniProtKB:A0A8M9P869 (1) | 595 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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