Gene

lrp6

ID
ZDB-GENE-090821-1
Name
low density lipoprotein receptor-related protein 6
Symbol
lrp6 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Ambiguous Mapping Details/Browsers
Description
Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in canonical Wnt signaling pathway and dorsal/ventral axis specification. Predicted to localize to plasma membrane and receptor complex. Is expressed in posterior lateral line primordium. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lrp6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
coronary artery disease Alliance {Coronary artery disease, autosomal dominant, 2} 610947
Tooth agenesis, selective, 7 616724
Associated With lrp6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000742 EGF-like domain
Family IPR017049 Low density lipoprotein receptor-related protein 5/6
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Repeat IPR000033 LDLR class B repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length EGF-like domain LDLR class B repeat LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Low density lipoprotein receptor-related protein 5/6 Six-bladed beta-propeller, TolB-like
UniProtKB:B5L5I6 1620
UniProtKB:A0A0R4IL75 935
Transcripts
Genome Browsers
No data available
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations