Gene
tfeb
- ID
- ZDB-GENE-090807-3
- Name
- transcription factor EB
- Symbol
- tfeb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within central nervous system myelination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; head; immature eye; mesoderm; and pronephros. Orthologous to human TFEB (transcription factor EB).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Meireles et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR021802 | MiT/TFE transcription factors, C-terminal |
| Domain | IPR024098 | Transcription factor EB, bHLHzip domain |
| Domain | IPR031867 | MiT/TFE transcription factors, N-terminal |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | MiT/TFE transcription factors, C-terminal | MiT/TFE transcription factors, N-terminal | Myc-type, basic helix-loop-helix (bHLH) domain | Transcription factor EB, bHLHzip domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7FEM8 | InterPro | 491 | |||||
| UniProtKB:A0A8M9Q799 | InterPro | 433 | |||||
| UniProtKB:A0A2R8RRI1 | InterPro | 493 | |||||
| UniProtKB:A0A8M2BK54 | InterPro | 325 | |||||
| UniProtKB:G5CIM3 | InterPro | 493 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-91M3 | ||
| Contained in | BAC | DKEY-105C22 | ZFIN Curated Data | |
| Encodes | EST | wz13340 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001257192 (1) | 1482 nt | ||
| Genomic | GenBank:CR853302 (2) | 231837 nt | ||
| Polypeptide | UniProtKB:A0A2R8RRI1 (1) | 493 aa |
- Della Vecchia, S., Imbrici, P., Liantonio, A., Naef, V., Damiani, D., Licitra, R., Bernardi, S., Marchese, M., Santorelli, F.M. (2025) Dapagliflozin ameliorates Lafora disease phenotype in a zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 183:117800117800
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Marchese, M., Bernardi, S., Ogi, A., Licitra, R., Silvi, G., Mero, S., Galatolo, D., Gammaldi, N., Doccini, S., Ratto, G.M., Rapposelli, S., Neuhauss, S.C.F., Zang, J., Rocchiccioli, S., Michelucci, E., Ceccherini, E., Santorelli, F.M. (2024) Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model. Neurobiology of disease. 197:106536
- Bouchard, E.L., Meireles, A.M., Talbot, W.S. (2023) Oligodendrocyte development and myelin sheath formation are regulated by the antagonistic interaction between the Rag-Ragulator complex and TFEB. Glia. 72(2):289-299
- Della Vecchia, S., Ogi, A., Licitra, R., Abramo, F., Nardi, G., Mero, S., Landi, S., Battini, R., Sicca, F., Ratto, G.M., Santorelli, F.M., Marchese, M. (2022) Trehalose Treatment in Zebrafish Model of Lafora Disease. International Journal of Molecular Sciences. 23(12)
- Iyer, H., Shen, K., Meireles, A.M., Talbot, W.S. (2022) A lysosomal regulatory circuit essential for the development and function of microglia. Science advances. 8:eabp8321
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Han, S.L., Qian, Y.C., Limbu, S.M., Wang, J., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2021) Lipolysis and lipophagy play individual and interactive roles in regulating triacylglycerol and cholesterol homeostasis and mitochondrial form in zebrafish. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(9):158988
- Ikeda, A., Komamizu, M., Hayashi, A., Yamasaki, C., Okada, K., Kawabe, M., Komatsu, M., Shiozaki, K. (2021) Neu1 deficiency induces abnormal emotional behavior in zebrafish. Scientific Reports. 11:13477
- Kim, M., Lu, L., Dvornikov, A.V., Ma, X., Ding, Y., Zhu, P., Olson, T.M., Lin, X., Xu, X. (2021) TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagCS75Y Cardiomyopathy. International Journal of Molecular Sciences. 22(11):
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