Gene
mroh1
- ID
- ZDB-GENE-090806-2
- Name
- maestro heat-like repeat family member 1
- Symbol
- mroh1 Nomenclature History
- Previous Names
-
- heatr7a
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to be active in cytoplasm. Orthologous to human MROH1 (maestro heat like repeat family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027726Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa22878 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22879 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42757 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42758 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR048465 | Maestro-like, HEAT-repeats domain |
| Domain | IPR055406 | Maestro/Maestro-like, HEAT-repeats domain |
| Domain | IPR055408 | MROH2B-like, HEAT-repeats domain |
| Domain | IPR056282 | MROH2B-like, N-terminal HEAT-repeats domain |
| Family | IPR045206 | Maestro heat-like repeat-containing protein |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | HEAT, type 2 | Maestro heat-like repeat-containing protein | Maestro-like, HEAT-repeats domain | Maestro/Maestro-like, HEAT-repeats domain | MROH2B-like, HEAT-repeats domain | MROH2B-like, N-terminal HEAT-repeats domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q5K7 | InterPro | 1399 | ||||||||
| UniProtKB:A0A8M6Z208 | InterPro | 1651 | ||||||||
| UniProtKB:A0A8M9PNQ9 | InterPro | 1651 | ||||||||
| UniProtKB:A0A8M9PUW6 | InterPro | 1642 | ||||||||
| UniProtKB:E7F6I0 | InterPro | 1642 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-197I17 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068218817 (1) | 8169 nt | ||
| Genomic | GenBank:BX569792 (2) | 234579 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z208 (1) | 1651 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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