Gene
f8
- ID
- ZDB-GENE-090629-2
- Name
- coagulation factor VIII, procoagulant component
- Symbol
- f8 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have copper ion binding activity and oxidoreductase activity. Involved in blood coagulation. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| factor VIII deficiency | Alliance | Hemophilia A | 306700 |
| Thrombophilia 13, X-linked, due to factor VIII defect | 301071 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR033138 | Multicopper oxidases, conserved site |
| Domain | IPR000421 | Coagulation factor 5/8 C-terminal domain |
| Domain | IPR011706 | Multicopper oxidase, C-terminal |
| Family | IPR024715 | Coagulation factor 5/8-like |
| Homologous_superfamily | IPR008972 | Cupredoxin |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Coagulation factor 5/8 C-terminal domain | Coagulation factor 5/8-like | Cupredoxin | Galactose-binding-like domain superfamily | Multicopper oxidase, C-terminal | Multicopper oxidases, conserved site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3BEX0
|
1668 |
Interactions and Pathways
No data available
Plasmids
No data available