Gene
tbx22
- ID
- ZDB-GENE-090626-2
- Name
- T-box transcription factor 22
- Symbol
- tbx22 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be active in chromatin and nucleus. Is expressed in mandibular arch skeleton; maxilla; paraxial mesoderm; and stomodeum. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and cleft palate. Orthologous to human TBX22 (T-box transcription factor 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Abruzzo-Erickson syndrome | Alliance | ?Abruzzo-Erickson syndrome | 302905 |
| X-linked cleft palate with or without ankyloglossia | Alliance | Cleft palate with ankyloglossia | 303400 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8Q7R4 | InterPro | 444 | |||||
| UniProtKB:C7FDJ4 | InterPro | 400 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-86F7 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001164461 (1) | 1969 nt | ||
| Genomic | GenBank:CR293501 (1) | 203705 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q7R4 (1) | 444 aa |
- Chen, W., Bian, C., You, X., Li, J., Ye, L., Wen, Z., Lv, Y., Zhang, X., Xu, J., Yang, S., Gu, R., Lin, X., Shi, Q. (2019) Genome Sequencing of the Japanese Eel (Anguilla japonica) for Comparative Genomic Studies on tbx4 and a tbx4 Gene Cluster in Teleost Fishes. Marine drugs. 17(7)
- Cosse-Etchepare, C., Gervi, I., Buisson, I., Formery, L., Schubert, M., Riou, J.F., Umbhauer, M., Le Bouffant, R. (2018) Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. The International journal of developmental biology. 62:325-333
- Jackson, H.W., Prakash, D., Litaker, M., Ferreira, T., Jezewski, P.A. (2015) Zebrafish Wnt9b Patterns the First Pharyngeal Arch into D-I-V Domains and Promotes Anterior-Medial Outgrowth. American Journal of Molecular Biology. 5(3):57-83
- Ahn, D., You, K.H., and Kim, C.H. (2012) Evolution of the Tbx6/16 Subfamily Genes in Vertebrates: Insights from Zebrafish. Mol. Biol. Evol.. 29(12):3959-3983
- Windner, S.E., Bird, N.C., Patterson, S.E., Doris, R.A., and Devoto, S.H. (2012) Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish. Biology Open. 1(8):806-814
- Swartz, M.E., Sheehan-Rooney, K., Dixon, M.J., and Eberhart, J.K. (2011) Examination of a palatogenic gene program in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(9):2204-2220
- Jezewski, P.A., Fang, P.K., Payne-Ferreira, T.L., and Yelick, P.C. (2009) Alternative splicing, phylogenetic analysis, and craniofacial expression of zebrafish tbx22. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(6):1605-1612
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