Gene

apc2

ID
ZDB-GENE-090422-1
Name
APC regulator of WNT signaling pathway 2
Symbol
apc2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have beta-catenin binding activity and gamma-catenin binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of microtubule depolymerization; and positive regulation of protein catabolic process. Predicted to colocalize with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Sotos syndrome and complex cortical dysplasia with other brain malformations. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With apc2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 74 Alliance Intellectual developmental disorder, autosomal recessive 74 617169
Sotos syndrome 3 Alliance Intellectual developmental disorder, autosomal recessive 74 617169
Cortical dysplasia, complex, with other brain malformations 10 618677
Associated With apc2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Protein Length
UniProtKB:A0A8M9QMA5 2119
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations