Gene

chrm3a

ID
ZDB-GENE-090410-4
Name
cholinergic receptor, muscarinic 3a
Symbol
chrm3a Nomenclature History
Previous Names
  • DrM3A (1)
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Enables G protein-coupled acetylcholine receptor activity. Acts upstream of or within cardiac conduction system development. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Is expressed in eye. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Nuckels et al., 2011
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Burczyk et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa42905Allele with one point mutationUnknownPremature StopENU
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-chrm3aN/ABurczyk et al., 2019
1 - 1 of 1
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Human Disease
Associated With chrm3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
prune belly syndrome Alliance Prune belly syndrome 100100
1 - 1 of 1
Associated With chrm3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000995 Muscarinic acetylcholine receptor family
Family IPR001183 Muscarinic acetylcholine receptor M3
1 - 4 of 4
Domain Details Per Protein
Protein Additional Resources Length GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Muscarinic acetylcholine receptor family Muscarinic acetylcholine receptor M3
UniProtKB:A0A8M9PNY8 InterPro 595
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA chrm3a-201 (1) Ensembl 3,277 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-97L21
Contained inBACDKEYP-90G2ZFIN Curated Data
1 - 2 of 2
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCHRM31
Amino acid sequence comparison (4)
Conserved genome location (synteny) (1)
Phylogenetic tree (1)
MouseChrm313
Phylogenetic tree (1)
Amino acid sequence comparison (1)
Citations
1 - 10 of 14
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