Gene
htr1ab
- ID
- ZDB-GENE-090409-2
- Name
- 5-hydroxytryptamine (serotonin) receptor 1A b
- Symbol
- htr1ab Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Acts upstream of or within spinal cord motor neuron differentiation. Predicted to be active in dendrite and plasma membrane. Is expressed in brain; pharynx; retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol dependence; anxiety disorder (multiple); depressive disorder; substance abuse; and withdrawal disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Barreiro-Iglesias et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| vesicoureteral reflux | Alliance | ?Periodic fever, menstrual cycle dependent | 614674 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 5-hydroxytryptamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:C0ITL9 | InterPro | 403 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
htr1ab-201
(1)
|
Ensembl | 1,212 nt | ||
| mRNA |
htr1ab-202
(1)
|
Ensembl | 1,438 nt |
Interactions and Pathways
No data available
Plasmids
No data available