Gene

quoa

ID

ZDB-GENE-090313-319

Name

quattro a

Symbol

quoa Nomenclature History

Previous Names

si:dkey-65j6.2 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Orthologous to human KIAA1755 (KIAA1755).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa11974	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa13463	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa32467	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Citations
CRISPR1-quoa		von der Heyde et al., 2020

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Human Disease

Associated With quoa Human Ortholog

No data available

Associated With quoa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR055251	SOS1/NGEF-like, PH domain
Family	IPR052231	Rho GEF and signaling-related domain-containing protein
Homologous_superfamily	IPR011993	PH-like domain superfamily

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Domain Details Per Protein

Protein	Additional Resources	Length	Dbl homology (DH) domain superfamily	Dbl homology domain	PH-like domain superfamily	Pleckstrin homology domain	Rho GEF and signaling-related domain-containing protein	SOS1/NGEF-like, PH domain
UniProtKB:A0A8M9PX25	InterPro	1583
UniProtKB:E7FCG7	InterPro	1588

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 23

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:dkey-65j6.2-201 (1) Ensembl	Ensembl	5,446 nt	Select Tool ZFIN BLAST
mRNA	si:dkey-65j6.2-202 (1) Ensembl	Ensembl	5,684 nt	Select Tool ZFIN BLAST
mRNA	si:dkey-65j6.2-203 (1) Ensembl	Ensembl	7,063 nt	Select Tool ZFIN BLAST
mRNA	si:dkey-65j6.2-204 (1) Ensembl	Ensembl	6,902 nt	Select Tool ZFIN BLAST
mRNA	si:dkey-65j6.2-205 (1) Ensembl	Ensembl	5,805 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-65J6	BX005287	ZFIN Curated Data
Contained in	BAC	DKEY-151K14	CR545469	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_009297130 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:BX004770 (1)	231131 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:E7FCG7 (1)	1588 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	KIAA1755	20	Ensembl:ENSG00000149633 Gene:85449 HGNC:29372	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	D630003M21Rik	2	Ensembl:ENSMUSG00000037813 Gene:228846 MGI:3606579	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

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