Gene

arhgef10lb

ID

ZDB-GENE-090313-222

Name

Rho guanine nucleotide exchange factor (GEF) 10-like b

Symbol

arhgef10lb Nomenclature History

Previous Names

arhgef10l
si:dkey-1c11.5

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have Rho guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of stress fiber assembly. Human ortholog(s) of this gene implicated in ovarian endometrial cancer and ovarian serous carcinoma. Orthologous to human ARHGEF10L (Rho guanine nucleotide exchange factor 10 like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef10lb Human Ortholog

No data available

Associated With arhgef10lb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Family	IPR039919	Rho guanine nucleotide exchange factor 10/17
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily

Domain Details Per Protein

Protein	Length	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	PH-like domain superfamily	Rho guanine nucleotide exchange factor 10/17	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M3ANP2 InterPro	1331
UniProtKB:A0A8M9Q7Y0 InterPro	1318
UniProtKB:A0A8M9PE05 InterPro	1348
UniProtKB:A0A8M3AMY5 InterPro	1225
UniProtKB:A0A8M9Q3S0 InterPro	1369

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgef10lb-202 (1) Ensembl	Havana	3114 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	arhgef10lb-203 (1) Ensembl	Havana	867 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations