Gene
plcl1
- ID
- ZDB-GENE-090313-194
- Name
- phospholipase C like 1
- Symbol
- plcl1 Nomenclature History
- Previous Names
-
- si:dkey-15m21.1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Predicted to be involved in several processes, including gamma-aminobutyric acid signaling pathway; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Predicted to be located in cytoplasm. Is expressed in hindbrain; lateral line nerve; and spinal cord. Orthologous to human PLCL1 (phospholipase C like 1 (inactive)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Takada et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
a323 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
la026917Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa2490 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa21517 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa31726 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34681 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa41457 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-plcl1 | Thyme et al., 2019 | |
CRISPR2-plcl1 | Thyme et al., 2019 | |
CRISPR3-plcl1 | Thyme et al., 2019 | |
CRISPR4-plcl1 | Thyme et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000008 | C2 domain |
Domain | IPR000909 | Phosphatidylinositol-specific phospholipase C, X domain |
Domain | IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
Domain | IPR001849 | Pleckstrin homology domain |
Domain | IPR015359 | Phosphoinositide-specific phospholipase C, EF-hand-like domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | EF-hand domain pair | PH-like domain superfamily | Phosphatidylinositol-specific phospholipase C, X domain | Phosphoinositide phospholipase C family | Phosphoinositide-specific phospholipase C, EF-hand-like domain | Phospholipase C, phosphatidylinositol-specific, Y domain | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily | Pleckstrin homology domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M1QKN6 | InterPro | 1137 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-117M22 | ZFIN Curated Data | |
Contained in | BAC | DKEY-15M21 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_001921763 (1) | |||
Genomic | GenBank:CR391943 (1) | 212667 nt | ||
Polypeptide | UniProtKB:A0A8M1QKN6 (1) | 1137 aa |
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Takada, N., and Appel, B. (2010) Identification of genes expressed by zebrafish oligodendrocytes using a differential microarray screen. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):2041-2047
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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