Gene

plcl1

ID
ZDB-GENE-090313-194
Name
phospholipase C like 1
Symbol
plcl1 Nomenclature History
Previous Names
  • si:dkey-15m21.1
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Predicted to be involved in several processes, including gamma-aminobutyric acid signaling pathway; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Predicted to be located in cytoplasm. Is expressed in hindbrain; lateral line nerve; and spinal cord. Orthologous to human PLCL1 (phospholipase C like 1 (inactive)).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Takada et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
a323Allele with multiple variantsUnknownUnknownCRISPR
la026917TgTransgenic insertionUnknownUnknownDNA
sa2490Allele with one point mutationUnknownSplice SiteENU
sa21517Allele with one point mutationUnknownSplice SiteENU
sa31726Allele with one point mutationUnknownPremature StopENU
sa34681Allele with one point mutationUnknownPremature StopENU
sa41457Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With plcl1 Human Ortholog
No data available
Associated With plcl1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000008 C2 domain
Domain IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
Domain IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
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Domain Details Per Protein
Protein Additional Resources Length C2 domain C2 domain superfamily EF-hand domain pair PH-like domain superfamily Phosphatidylinositol-specific phospholipase C, X domain Phosphoinositide phospholipase C family Phosphoinositide-specific phospholipase C, EF-hand-like domain Phospholipase C, phosphatidylinositol-specific, Y domain PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily Pleckstrin homology domain
UniProtKB:A0A8M1QKN6 InterPro 1137
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 9
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA plcl1-201 (1) Ensembl 3,376 nt
mRNA plcl1-202 (1) Ensembl 2,772 nt
mRNA plcl1-203 (1) Ensembl 3,093 nt
mRNA plcl1-204 (1) Ensembl 3,030 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-117M22ZFIN Curated Data
Contained inBACDKEY-15M21ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPLCL12
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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