Gene
bcl9
- ID
- ZDB-GENE-090313-135
- Name
- BCL9 transcription coactivator
- Symbol
- bcl9 Nomenclature History
- Previous Names
-
- si:ch73-15j19.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable beta-catenin binding activity. Acts upstream of or within embryonic viscerocranium morphogenesis and regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF complex. Orthologous to human BCL9 (BCL9 transcription coactivator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Shull et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Cantù et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-bcl9 | (2) | |
| CRISPR2-bcl9 | Sun et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | B Cell Lymphoma 9 | B-cell lymphoma 9, beta-catenin binding domain | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|
| UniProtKB:Q67FY0 | InterPro | 1474 | |||
| UniProtKB:F1R405 | InterPro | 1573 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-15J19 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-229O2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198393 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005604 (1) | 4456 nt | ||
| Genomic | GenBank:BX276127 (1) | 149775 nt | ||
| Polypeptide | UniProtKB:F1R405 (1) | 1573 aa |
- Shull, L.C., Lencer, E.S., Kim, H.M., Goyama, S., Kurokawa, M., Costello, J.C., Jones, K., Artinger, K.B. (2022) PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation. Development (Cambridge, England). 149(4):
- Zhao, W., Yuan, P., Hu, N., Long, D., Ding, D., Wang, H. (2020) Effects of Low-Dose Gamma-Ray Radiation on Apoptosis and Development of Zebrafish Embryo Brain. Radiation Research. 194(1):61-70
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Cantù, C., Felker, A., Zimmerli, D., Prummel, K.D., Cabello, E.M., Chiavacci, E., Méndez-Acevedo, K.M., Kirchgeorg, L., Burger, S., Ripoll, J., Valenta, T., Hausmann, G., Vilain, N., Aguet, M., Burger, A., Panáková, D., Basler, K., Mosimann, C. (2018) Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.. Genes & Development. 32(21-22):1443-1458
- Black, J.C., Atabakhsh, E., Kim, J., Biette, K.M., Van Rechem, C., Ladd, B., Burrowes, P.D., Donado, C., Mattoo, H., Kleinstiver, B.P., Song, B., Andriani, G., Joung, J.K., Iliopoulos, O., Montagna, C., Pillai, S., Getz, G., Whetstine, J.R. (2015) Hypoxia drives transient site-specific copy gain and drug-resistant gene expression. Genes & Development. 29:1018-31
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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