Gene
cpeb3
- ID
- ZDB-GENE-090312-68
- Name
- cytoplasmic polyadenylation element binding protein 3
- Symbol
- cpeb3 Nomenclature History
- Previous Names
-
- si:ch211-129m12.2
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including mRNA 3'-UTR binding activity; mRNA regulatory element binding translation repressor activity; and translation factor activity, RNA binding. Predicted to be involved in long-term memory; negative regulation of cytoplasmic translation; and regulation of postsynapse assembly. Predicted to act upstream of or within regulation of translation. Predicted to be active in several cellular components, including neuron projection; nucleus; and synapse. Orthologous to human CPEB3 (cytoplasmic polyadenylation element binding protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018636Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6328 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12175 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17508 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42284 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR032296 | Cytoplasmic polyadenylation element-binding protein, ZZ domain |
| Family | IPR034819 | Cytoplasmic polyadenylation element-binding protein |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CEBP, ZZ domain superfamily | Cytoplasmic polyadenylation element-binding protein | Cytoplasmic polyadenylation element-binding protein, ZZ domain | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B5H6 | InterPro | 613 | ||||||
| UniProtKB:A0A8M3B893 | InterPro | 636 | ||||||
| UniProtKB:D0PNH8 | InterPro | 586 | ||||||
| UniProtKB:A0A8M2BGS8 | InterPro | 621 | ||||||
| UniProtKB:A0A8M3AZE0 | InterPro | 644 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-129M12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001167662 (1) | 1906 nt | ||
| Genomic | GenBank:BX005050 (1) | 166695 nt | ||
| Polypeptide | UniProtKB:A0A8M3AZE0 (1) | 644 aa |
- Ford, C., de Sena-Tomás, C., Wun, T.T.R., Aleman, A.G., Rangaswamy, U., Leyhr, J., Nuñez, M.I., Gao, C.Z., Nim, H.T., See, M., Coppola, U., Waxman, J.S., Ramialison, M., Haitina, T., Smeeton, J., Sanges, R., Targoff, K.L. (2025) Nkx2.7 is a conserved regulator of craniofacial development. Nature communications. 16:38023802
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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