Gene
cpeb3
- ID
- ZDB-GENE-090312-68
- Name
- cytoplasmic polyadenylation element binding protein 3
- Symbol
- cpeb3 Nomenclature History
- Previous Names
-
- si:ch211-129m12.2
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including mRNA 3'-UTR binding activity; mRNA regulatory element binding translation repressor activity; and translation factor activity, RNA binding. Predicted to be involved in negative regulation of cytoplasmic translation. Predicted to act upstream of or within regulation of translation. Predicted to be active in several cellular components, including neuron projection; nucleus; and synapse. Orthologous to human CPEB3 (cytoplasmic polyadenylation element binding protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018636Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6328 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12175 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17508 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42284 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR032296 | Cytoplasmic polyadenylation element-binding protein, ZZ domain |
| Family | IPR034819 | Cytoplasmic polyadenylation element-binding protein |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CEBP, ZZ domain superfamily | Cytoplasmic polyadenylation element-binding protein | Cytoplasmic polyadenylation element-binding protein, ZZ domain | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B5H6 | InterPro | 613 | ||||||
| UniProtKB:A0A8M3B893 | InterPro | 636 | ||||||
| UniProtKB:D0PNH8 | InterPro | 586 | ||||||
| UniProtKB:A0A8M2BGS8 | InterPro | 621 | ||||||
| UniProtKB:A0A8M3AZE0 | InterPro | 644 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-129M12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001167662 (1) | 1906 nt | ||
| Genomic | GenBank:BX005050 (1) | 166695 nt | ||
| Polypeptide | UniProtKB:A0A8M3AZE0 (1) | 644 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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