ZFIN is now using GRCz12tu for Genomic Data
Gene
camta1a
- ID
- ZDB-GENE-090312-183
- Name
- calmodulin binding transcription activator 1a
- Symbol
- camta1a Nomenclature History
- Previous Names
-
- si:dkey-223i19.5
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable double-stranded DNA binding activity and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in nonprogressive cerebellar ataxia with mental retardation. Orthologous to human CAMTA1 (calmodulin binding transcription activator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Diotel et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la022642Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022643Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022644Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022645Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022646Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028541Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa24366 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa44016 | Allele with one point mutation | Unknown | Unknown | ENU | |
| uab458 | Allele with multiple variants | Unknown | Unknown | CRISPR |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonprogressive cerebellar ataxia with mental retardation | Alliance | Cerebellar dysfunction with variable cognitive and behavioral abnormalities | 614756 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | CG-1 DNA-binding domain | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | IQ motif, EF-hand binding site | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PFK5 | InterPro | 1817 | ||||||||
| UniProtKB:A0A8M9Q822 | InterPro | 1578 | ||||||||
| UniProtKB:A0A8M9PWY3 | InterPro | 1771 | ||||||||
| UniProtKB:A0A8M9PQV2 | InterPro | 726 | ||||||||
| UniProtKB:A0A8M9Q3X1 | InterPro | 1550 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
camta1a-201
(1)
|
Ensembl | 9,500 nt | ||
| mRNA |
camta1a-202
(1)
|
Ensembl | 603 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-67F18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-223I19 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-78A6 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005162333 (1) | GRCz12tu | 9906 nt | |
| Genomic | GenBank:CR753893 (1) | 197503 nt | ||
| Polypeptide | UniProtKB:A0A8M9P5K3 (1) | 1818 aa |
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Ebrahimie, E., Moussavi-Nik, S.H., Newman, M., Van Der Hoek, M., Lardelli, M. (2016) The Zebrafish Equivalent of Alzheimer's Disease-Associated PRESENILIN Isoform PS2V Regulates Inflammatory and Other Responses to Hypoxic Stress. Journal of Alzheimer's disease : JAD. 52(2):581-608
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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