Gene

alox5a

ID
ZDB-GENE-090311-47
Name
arachidonate 5-lipoxygenase a
Symbol
alox5a Nomenclature History
Previous Names
  • ALOX2 (1)
  • alox5
  • LOX2 (1)
  • si:dkey-194n13.2
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits arachidonate 5-lipoxygenase activity; arachidonic acid monooxygenase activity; and leukotriene-C4 synthase activity. Involved in arachidonic acid metabolic process. Human ortholog(s) of this gene implicated in arteriosclerosis; asthma; pancreatic cancer; pulmonary hypertension; and pulmonary tuberculosis. Is expressed in pronephric duct. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With alox5a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
asthma Alliance {Asthma, diminished response to antileukotriene treatment in} 600807
{Atherosclerosis, susceptibility to}
Associated With alox5a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR020833 Lipoxygenase, iron binding site
Conserved_site IPR020834 Lipoxygenase, conserved site
Domain IPR001024 PLAT/LH2 domain
Domain IPR013819 Lipoxygenase, C-terminal
Domain IPR042062 Lipoxygenase, vertebrates, PLAT domain
Family IPR000907 Lipoxygenase
Family IPR001885 Lipoxygenase, mammalian
Homologous_superfamily IPR036226 Lipoxigenase, C-terminal domain superfamily
Homologous_superfamily IPR036392 PLAT/LH2 domain superfamily
Domain Details Per Protein
Protein Length Lipoxigenase, C-terminal domain superfamily Lipoxygenase Lipoxygenase, conserved site Lipoxygenase, C-terminal Lipoxygenase, iron binding site Lipoxygenase, mammalian Lipoxygenase, vertebrates, PLAT domain PLAT/LH2 domain PLAT/LH2 domain superfamily
UniProtKB:B8A697 674
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations