Gene
alox5a
- ID
- ZDB-GENE-090311-47
- Name
- arachidonate 5-lipoxygenase a
- Symbol
- alox5a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables arachidonate 5-lipoxygenase activity; arachidonate monooxygenase activity; and leukotriene-C4 synthase activity. Acts upstream of or within arachidonate metabolic process and inflammatory response to wounding. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in pronephric duct. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mk211 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa1464 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6291 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12277 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17538 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22263 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35451 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42170 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Lipoxigenase, C-terminal domain superfamily | Lipoxygenase | Lipoxygenase, conserved site | Lipoxygenase, C-terminal | Lipoxygenase, iron binding site | Lipoxygenase, mammalian | Lipoxygenase, vertebrates, PLAT domain | PLAT/LH2 domain | PLAT/LH2 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8A697 | InterPro | 674 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
alox5a-201
(1)
|
Ensembl | 2,039 nt | ||
| ncRNA |
alox5a-002
(1)
|
Ensembl | 489 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(lyz:TagRFP-alox5a) |
|
| 1 | Poplimont et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-194N13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-228D14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256747 (1) | 2036 nt | ||
| Genomic | GenBank:BX927098 (1) | 229413 nt | ||
| Polypeptide | UniProtKB:B8A697 (1) | 674 aa |
- Liu, Q., Song, T., Chen, B., Zhang, J., Li, W. (2023) Ferroptosis of brain microvascular endothelial cells contributes to hypoxia-induced blood-brain barrier injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22874e22874
- Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):
- Ma, Y., Hui, K.L., Gelashvili, Z., Niethammer, P. (2023) Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish. Cell Reports. 42:111974111974
- Siddiqui, A., Abidin, S.A.Z., Shah, Z.A., Othman, I., Kumari, Y. (2023) Behavioural, genomics and proteomic approach to examine Alzheimer's disease in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 271:109636
- Shin, K.C., Lee, J., Oh, D.K. (2022) Characterization of Arachidonate 5S-Lipoxygenase from Danio rerio with High Activity for the Production of 5S- and 7S-Hydroxy Polyunsaturated Fatty Acids. Applied Biochemistry and Biotechnology. 195(2):958-972
- Katikaneni, A., Jelcic, M., Gerlach, G.F., Ma, Y., Overholtzer, M., Niethammer, P. (2020) Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish. Nature cell biology. 22(9):1049-1055
- Mu, X., Chen, X., Liu, J., Yuan, L., Wang, D., Qian, L., Qian, Y., Shen, G., Huang, Y., Li, X., Li, Y., Lin, X. (2020) A multi-omics approach reveals molecular mechanisms by which phthalates induce cardiac defects in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:113876
- Nayak, S., Al Ashhab, A., Zilberg, D., Khozin-Goldberg, I. (2020) Dietary Supplementation with Omega-6 LC-PUFA-Rich Microalgae Regulates Mucosal Immune Response and Promotes Microbial Diversity in the Zebrafish Gut. Biology. 9(6):
- Poplimont, H., Georgantzoglou, A., Boulch, M., Walker, H.A., Coombs, C., Papaleonidopoulou, F., Sarris, M. (2020) Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals. Current biology : CB. 30(14):2761-2776.e7
- Xu, S., Xie, F., Tian, L., Manno, S.H., Manno, F.A.M., Cheng, S.H. (2019) Prolonged neutrophil retention in the wound impairs zebrafish heart regeneration after cryoinjury. Fish & shellfish immunology. 94:447-454
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