Gene
mapk8ip3
- ID
- ZDB-GENE-090303-6
- Name
- mitogen-activated protein kinase 8 interacting protein 3
- Symbol
- mapk8ip3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables cargo adaptor activity. Acts upstream of or within axon extension; regulation of JNK cascade; and retrograde axonal protein transport. Predicted to be active in cytoplasm. Is expressed in central nervous system; peripheral nervous system; and posterior lateral line ganglion. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Drerup et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with or without variable brain abnormalities | 618443 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR032486 | JNK-interacting protein, leucine zipper II |
| Domain | IPR034743 | RH1 domain |
| Domain | IPR034744 | RH2 domain |
| Family | IPR039911 | JNK-interacting protein 3/4 |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | JNK-interacting protein 3/4 | JNK-interacting protein, leucine zipper II | RH1 domain | RH2 domain | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:L7RKJ8 | InterPro | 1299 | ||||||
| UniProtKB:A0AB13A9J8 | InterPro | 1311 | ||||||
| UniProtKB:A0AB13AB31 | InterPro | 1334 | ||||||
| UniProtKB:A0AB13ABF1 | InterPro | 1275 | ||||||
| UniProtKB:A0A8M1P724 | InterPro | 1300 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mapk8ip3-201
(1)
|
Ensembl | 5,409 nt | ||
| mRNA |
mapk8ip3-202
(1)
|
Ensembl | 3,900 nt |
Interactions and Pathways
No data available
Plasmids
No data available