Gene

nectin1a

ID

ZDB-GENE-090224-1

Name

nectin cell adhesion molecule 1a

Symbol

nectin1a Nomenclature History

Previous Names

nectin-1a (1)
pvrl1a (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable cell adhesion mediator activity and virus receptor activity. Acts upstream of or within primary palate development. Predicted to be located in anchoring junction and membrane. Predicted to be active in adherens junction; apical junction complex; and plasma membrane. Is expressed in several structures, including hindbrain; mandibular arch skeleton; optic vesicle; solid lens vesicle; and visual system. Human ortholog(s) of this gene implicated in cleft lip; cleft lip-palate-ectodermal dysplasia syndrome; cleft palate; and ectodermal dysplasia. Orthologous to human NECTIN1 (nectin cell adhesion molecule 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Liu et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nectin1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cleft lip-palate-ectodermal dysplasia syndrome	Alliance	Cleft lip/palate-ectodermal dysplasia syndrome	225060
cleft lip-palate-ectodermal dysplasia syndrome	Alliance	Orofacial cleft 7	225060

Associated With nectin1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013106	Immunoglobulin V-set domain
Domain	IPR013162	CD80-like, immunoglobulin C2-set
Family	IPR051427	Nectin and Nectin-like
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2B818	InterPro	479
UniProtKB:A0A8M2B8A6	InterPro	496
UniProtKB:B0JYH7	InterPro	475
UniProtKB:A0AB12ZHN2	InterPro	475
UniProtKB:A0AB13S943	InterPro	496
UniProtKB:A0AB32TCW3	InterPro	458
UniProtKB:A0AB75PZ23	InterPro	479