Gene
gnrhr3
- ID
- ZDB-GENE-090128-1
- Name
- gonadotropin releasing hormone receptor 3
- Symbol
- gnrhr3 Nomenclature History
- Previous Names
-
- GnRH-R3PEY (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables gonadotropin-releasing hormone receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including female organism; gut; male organism; nervous system; and pleuroperitoneal region. Orthologous to human GNRHR2 (gonadotropin releasing hormone receptor 2 (pseudogene)).
- Genome Resources
-
- Alliance (1)
- Gene:564687 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Gonadotrophin-releasing hormone receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:B9P4N5 | InterPro | 336 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001177450 (1) | 1011 nt | ||
| Genomic | GenBank:CABZ01080435 (1) | 27942 nt | ||
| Polypeptide | UniProtKB:B9P4N5 (1) | 336 aa |
- Comparative Orthology
- Alliance
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Duan, M., Guo, X., Chen, X., Guo, M., Xu, H., Hao, L., Wang, C., Yang, Y. (2022) Life Cycle Exposure to Cyhalofop-Butyl Induced Reproductive Toxicity in Zebrafish. Toxics. 10(9)
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Marvel, M., Levavi-Sivan, B., Wong, T.T., Zmora, N., Zohar, Y. (2021) Gnrh2 maintains reproduction in fasting zebrafish through dynamic neuronal projection changes and regulation of gonadotropin synthesis, oogenesis, and reproductive behaviors. Scientific Reports. 11:6657
- Fallah, H.P., Rodrigues, M.S., Corchuelo, S., Nóbrega, R.H., Habibi, H.R. (2020) Role of GnRH isoforms in paracrine/autocrine control of zebrafish (Danio rerio) spermatogenesis. Endocrinology. 161(2):
- Lu, J., Wu, Q., Yang, Q., Li, G., Wang, R., Liu, Y., Duan, C., Duan, S., He, X., Huang, Z., Peng, X., Yan, W., Jiang, J. (2020) Molecular mechanism of reproductive toxicity induced by beta-cypermethrin in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 239:108894
- Teng, M., Wang, C., Song, M., Chen, X., Zhang, J., Wang, C. (2020) Chronic exposure of zebrafish (Danio rerio) to flutolanil leads to endocrine disruption and reproductive disorders. Environmental research. 184:109310
- Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
- Bao, M., Huang, W., Au, W.W., Zheng, S., Liu, C., Huang, Y., Wu, K. (2019) Exposure to perfluorooctane sulfonate based on circadian rhythm changes the fecundity and expression of certain genes on the hypothalamic-pituitary-gonadal-liver axis of female zebrafish. Toxicology and applied pharmacology. 381:114715
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