Gene

dock4a

ID
ZDB-GENE-090112-1
Name
dedicator of cytokinesis 4a
Symbol
dock4a Nomenclature History
Previous Names
  • si:dkey-81e3.1 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Acts upstream of or within canonical Wnt signaling pathway and erythrocyte development. Predicted to be active in cytoplasm and plasma membrane.
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Sundaravel et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa9878Allele with one point mutationUnknownPremature StopENU
sa15407Allele with one point mutationUnknownPremature StopENU
sa32532Allele with one point mutationUnknownPremature StopENU
sa38070Allele with one point mutationUnknownPremature StopENU
sa38071Allele with one point mutationUnknownSplice SiteENU
sa38072Allele with one point mutationUnknownSplice SiteENU
sa38073Allele with one point mutationUnknownSplice SiteENU
sa44300Allele with one point mutationUnknownPremature StopENU
sa44301Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-dock4aN/A (2)
MO2-dock4aN/ASundaravel et al., 2015
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Human Disease
Associated With dock4a Human Ortholog
No data available
Associated With dock4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001452 SH3 domain
Domain IPR027007 C2 DOCK-type domain
Domain IPR027357 DOCKER domain
Domain IPR032376 Dedicator of cytokinesis, N-terminal domain
Domain IPR035769 Dedicator of cytokinesis 4, SH3 domain
1 - 5 of 16 Show all
Domain Details Per Protein
Protein Additional Resources Length C2 DOCK-type domain C2 domain superfamily Dedicator of cytokinesis Dedicator of cytokinesis 4, SH3 domain Dedicator of cytokinesis B, C2 domain Dedicator of cytokinesis, C-terminal, lobe A Dedicator of cytokinesis, C-terminal, lobe C Dedicator of cytokinesis, N-terminal domain Dedicator of cytokinesis, N-terminal, subdomain 1 Dedicator of cytokinesis, TPR repeats region DOCKER domain DOCKER, Lobe A DOCKER, Lobe B DOCKER, Lobe C SH3 domain SH3-like domain superfamily
UniProtKB:K7DY59 InterPro 1925
UniProtKB:A0A8M9PEG0 InterPro 1642
UniProtKB:A0A8M9Q470 InterPro 1925
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA dock4a-201 (1) Ensembl 7,428 nt
mRNA dock4a-202 (1) Ensembl 2,027 nt
mRNA dock4a-203 (1) Ensembl 396 nt
mRNA dock4a-204 (1) Ensembl 549 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-81E3ZFIN Curated Data
Contained inBACDKEY-150F14ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanDOCK47
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
Phylogenetic tree (1)
MouseDock412
Phylogenetic tree (1)
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 5 of 5
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