Gene
dock4a
- ID
- ZDB-GENE-090112-1
- Name
- dedicator of cytokinesis 4a
- Symbol
- dock4a Nomenclature History
- Previous Names
-
- si:dkey-81e3.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Acts upstream of or within canonical Wnt signaling pathway and erythrocyte development. Predicted to be active in cytoplasm and plasma membrane.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sundaravel et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa9878 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa15407 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32532 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38070 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38071 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa38072 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa38073 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa44300 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa44301 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-dock4a | N/A | (2) |
MO2-dock4a | N/A | Sundaravel et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | C2 DOCK-type domain | C2 domain superfamily | Dedicator of cytokinesis | Dedicator of cytokinesis 4, SH3 domain | Dedicator of cytokinesis B, C2 domain | Dedicator of cytokinesis, C-terminal, lobe A | Dedicator of cytokinesis, C-terminal, lobe C | Dedicator of cytokinesis, N-terminal domain | Dedicator of cytokinesis, N-terminal, subdomain 1 | Dedicator of cytokinesis, TPR repeats region | DOCKER domain | DOCKER, Lobe A | DOCKER, Lobe B | DOCKER, Lobe C | SH3 domain | SH3-like domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:K7DY59 | InterPro | 1925 | ||||||||||||||||
UniProtKB:A0A8M9PEG0 | InterPro | 1642 | ||||||||||||||||
UniProtKB:A0A8M9Q470 | InterPro | 1925 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
dock4a-201
(1)
|
Ensembl | 7,428 nt | ||
mRNA |
dock4a-202
(1)
|
Ensembl | 2,027 nt | ||
mRNA |
dock4a-203
(1)
|
Ensembl | 396 nt | ||
mRNA |
dock4a-204
(1)
|
Ensembl | 549 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-81E3 | ZFIN Curated Data | |
Contained in | BAC | DKEY-150F14 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_005170698 (1) | 6744 nt | ||
Genomic | GenBank:CR759824 (1) | 174086 nt | ||
Polypeptide | UniProtKB:A0A8M9Q470 (1) | 1925 aa |
- Kedra, M., Banasiak, K., Kisielewska, K., Wolinska-Niziol, L., Jaworski, J., Zmorzynska, J. (2020) TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex. Proceedings of the National Academy of Sciences of the United States of America. 117(4):2170-2179
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Sundaravel, S., Duggan, R., Bhagat, T., Ebenezer, D.L., Liu, H., Yu, Y., Bartenstein, M., Unnikrishnan, M., Karmakar, S., Liu, T.C., Torregroza, I., Quenon, T., Anastasi, J., McGraw, K.L., Pellagatti, A., Boultwood, J., Yajnik, V., Artz, A., Le Beau, M.M., Steidl, U., List, A.F., Evans, T., Verma, A., Wickrema, A. (2015) Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes. Proceedings of the National Academy of Sciences of the United States of America. 112:E6359-68
- Upadhyay, G., Goessling, W., North, T.E., Xavier, R., Zon, L.I., and Yajnik, V. (2008) Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling. Oncogene. 27(44):5845-5855
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