Gene
prkaa2
- ID
- ZDB-GENE-081120-5
- Name
- protein kinase, AMP-activated, alpha 2 catalytic subunit
- Symbol
- prkaa2 Nomenclature History
- Previous Names
-
- ampka2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cellular response to glucose starvation and negative regulation of TOR signaling. Predicted to act upstream of or within several processes, including Wnt signaling pathway; cholesterol biosynthetic process; and protein phosphorylation. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zang et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR028783 | PRKAA2, UBA-like autoinhibitory domain |
| Domain | IPR032270 | AMPK, C-terminal adenylate sensor domain |
| Domain | IPR049020 | PRKAA1/2, autoinhibitory domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR028375 | KA1 domain/Ssp2, C-terminal |
Domain Details Per Protein
| Protein | Additional Resources | Length | AMPK, C-terminal adenylate sensor domain | KA1 domain/Ssp2, C-terminal | PRKAA1/2, autoinhibitory domain | PRKAA2, UBA-like autoinhibitory domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F9C4 | InterPro | 553 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkaa2-201
(1)
|
Ensembl | 3,579 nt |
Interactions and Pathways
No data available
Plasmids
No data available