ZFIN is now using GRCz12tu for Genomic Data
Gene
frem1a
- ID
- ZDB-GENE-081119-1
- Name
- Fras1 related extracellular matrix 1a
- Symbol
- frem1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable carbohydrate binding activity and metal ion binding activity. Acts upstream of or within fin morphogenesis. Predicted to be located in basement membrane and membrane. Predicted to be active in extracellular matrix. Is expressed in fin fold pectoral fin bud; median fin fold; pectoral fin; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001304 | C-type lectin-like |
| Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
| Domain | IPR045658 | FRAS1-related extracellular matrix protein, N-terminal domain |
| Family | IPR051561 | FRAS1-related extracellular matrix |
| Homologous_superfamily | IPR016186 | C-type lectin-like/link domain superfamily |
| Homologous_superfamily | IPR016187 | C-type lectin fold |
| Homologous_superfamily | IPR038081 | CalX-like domain superfamily |
| Repeat | IPR039005 | CSPG repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | CalX-like domain superfamily | CSPG repeat | C-type lectin fold | C-type lectin-like | C-type lectin-like/link domain superfamily | FRAS1-related extracellular matrix | FRAS1-related extracellular matrix protein, N-terminal domain | Na-Ca exchanger/integrin-beta4 |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:D7PS89 | InterPro | 2167 | ||||||||
| UniProtKB:A0A8M1NUJ1 | InterPro | 2167 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
frem1a-201
(1)
|
Ensembl | 7,217 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers