Gene
ppp3r1a
- ID
- ZDB-GENE-081113-3
- Name
- protein phosphatase 3, regulatory subunit B, alpha a
- Symbol
- ppp3r1a Nomenclature History
- Previous Names
-
- ppp3r1
- si:ch211-274c22.8
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity and phosphatase binding activity. Predicted to be involved in calcineurin-mediated signaling. Predicted to be part of calcineurin complex. Is expressed in brain; heart; inner ear; and swim bladder. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair |
|---|---|---|---|---|---|
| UniProtKB:A0A8M3BEF6 | InterPro | 175 | |||
| UniProtKB:E9QG20 | InterPro | 170 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppp3r1a-201
(1)
|
Ensembl | 1,203 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Huang, Y., Wang, W.F., Huang, C.X., Li, X.H., Liu, H., Wang, H.L. (2022) miR-731 modulates the zebrafish heart morphogenesis via targeting Calcineurin/Nfatc3a pathway. Biochimica et biophysica acta. General subjects. 1866(6):130133
- Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668
- Nascimento, L.R.D., Vieira-Silva, G.A., Kitajima, J.P.F.W., Batissoco, A.C., Lezirovitz, K. (2022) New Insights into the Identity of the DFNA58 Gene. Genes. 13(12):
- Reddy, B.R., Babu, N.S., Das, T., Bhattacharya, D., Murthy, C.L.N., Kumar, A., Idris, M.M., Chakravarty, S. (2021) Proteome profile of telencephalon associates attenuated neurogenesis with chronic stress induced mood disorder phenotypes in zebrafish model. Pharmacology, biochemistry, and behavior. 204:173170
- Shi, X., Zhang, Y., Chen, R., Gong, Y., Zhang, M., Guan, R., Rotstein, O.D., Liu, X., Wen, X.Y. (2020) ndufa7 plays a critical role in cardiac hypertrophy. Journal of Cellular and Molecular Medicine. 24(22):13151-13162
- Shi, X., Zhang, Y., Gong, Y., Chen, M., Brand-Arzamendi, K., Liu, X., Wen, X.Y. (2020) Zebrafish hhatla is involved in cardiac hypertrophy. Journal of Cellular Physiology. 236(5):3700-3709
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Fin, L., Bergamin, G., Steiner, R.A., Hughes, S.M. (2017) The Cannabinoid Receptor Interacting Proteins 1 of zebrafish are not required for morphological development, viability or fertility. Scientific Reports. 7:4858
- Babu, N.S., Murthy, C.L., Kakara, S., Sharma, R., Swamy, C.V., Idris, M.M. (2016) MPTP induced Parkinson's disease in zebrafish. Proteomics. 16(9):1407-20
- Fredericksen, F., Villalba, M., Olavarría, V.H. (2016) Characterization of bovine A20 gene: Expression mediated by NF-κB pathway in MDBK cells infected with bovine viral diarrhea virus-1. Gene. 581(2):117-29
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