Gene
prop1
- ID
- ZDB-GENE-081107-40
- Name
- PROP paired-like homeobox 1
- Symbol
- prop1 Nomenclature History
- Previous Names
-
- si:ch211-93n23.5 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within adenohypophysis development. Predicted to be active in nucleus. Is expressed in hypophysis. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency 2; hypogonadism; and hypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Angotzi et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined pituitary hormone deficiency 2 | Alliance | Pituitary hormone deficiency, combined, 2 | 262600 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein prophet of Pit-1 | Homeodomain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QKN2 | InterPro | 227 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-93N23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001177461 (1) | 852 nt | ||
| Genomic | GenBank:AL954180 (1) | 225504 nt | ||
| Polypeptide | UniProtKB:A0A2R8QKN2 (1) | 227 aa |
- Ventura Fernandes, B.H., Junqueira, M.S., MacRae, C., Silveira de Carvalho, L.R. (2024) Standardizing CRISPR-Cas13 knockdown technique to investigate the role of cdh2 gene in pituitary development through growth hormone expression and transcription factors. Frontiers in endocrinology. 15:14666381466638
- Fabian, P., Tseng, K.C., Smeeton, J., Lancman, J.J., Dong, P.D.S., Cerny, R., Crump, J.G. (2020) Lineage analysis reveals an endodermal contribution to the vertebrate pituitary. Science (New York, N.Y.). 370:463-467
- Nakahara, Y., Muto, A., Hirabayashi, R., Sakuma, T., Yamamoto, T., Kume, S., Kikuchi, Y. (2016) Temporal effects of Notch signaling and potential cooperation with multiple downstream effectors on adenohypophysis cell specification in zebrafish. Genes to cells : devoted to molecular & cellular mechanisms. 21(5):492-504
- Angotzi, A.R., Mungpakdee, S., Stefansson, S., Male, R., and Chourrout, D. (2011) Involvement of Prop1 homeobox gene in the early development of fish pituitary gland. General and comparative endocrinology. 171(3):332-340
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