Gene
pkdcca
- ID
- ZDB-GENE-081107-30
- Name
- protein kinase domain containing, cytoplasmic a
- Symbol
- pkdcca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in skeletal system development. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in Golgi apparatus. Predicted to be active in extracellular region. Is expressed in eye; fin bud; margin; and pharyngeal arch 3-7. Orthologous to human PKDCC (protein kinase domain containing, cytoplasmic).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027423Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9725 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15357 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Rhizomelic limb shortening with dysmorphic features | 618821 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Extracellular tyrosine-protein kinase PKDCC | FAM69, protein-kinase domain | Protein kinase domain | Protein kinase-like domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:C4B4T7 | InterPro | 516 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pkdcca-201
(1)
|
Ensembl | 1,693 nt | ||
| mRNA |
pkdcca-202
(1)
|
Ensembl | 1,178 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-226D5 | ||
| Contained in | BAC | CH211-239I4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001161598 (1) | 1693 nt | ||
| Genomic | RefSeq:NW_018394861 (1) | 256327 nt | ||
| Polypeptide | UniProtKB:C4B4T7 (1) | 516 aa |
- Satija, R., Farrell, J.A., Gennert, D., Schier, A.F., Regev, A. (2015) Spatial reconstruction of single-cell gene expression data. Nat. Biotechnol.. 33(5):495-502
- Melvin, V.S., Feng, W., Hernandez-Lagunas, L., Artinger, K.B., and Williams, T. (2013) A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(7):817-31
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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