Gene
syn1
- ID
- ZDB-GENE-081105-93
- Name
- synapsin I
- Symbol
- syn1 Nomenclature History
- Previous Names
-
- si:dkey-90n12.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and actin binding activity. Predicted to be involved in synapse organization and synaptic vesicle clustering. Predicted to act upstream of or within neurotransmitter secretion. Predicted to be located in Golgi apparatus; cell projection; and synaptic vesicle. Predicted to be active in synaptic vesicle membrane. Is expressed in DEL; nervous system; spinal cord neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders and non-syndromic X-linked intellectual disability 50. Orthologous to human SYN1 (synapsin I).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7143 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12369 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21334 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21335 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34436 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| non-syndromic X-linked intellectual disability 50 | Alliance | Intellectual developmental disorder, X-linked 50 | 300115 |
| X-linked epilepsy with variable learning disabilities and behavior disorders | Alliance | Epilepsy, X-linked 1, with variable learning disabilities and behavior disorders | 300491 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-grasp fold, subdomain 1 | Pre-ATP-grasp domain superfamily | Synapsin | Synapsin, ATP-binding domain | Synapsin, conserved site | Synapsin, phosphorylation site | Synapsin, pre-ATP-grasp domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0UXI4 | InterPro | 670 | |||||||
| UniProtKB:A0A8M2BEL9 | InterPro | 633 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(10xUAS-E1B:syn1-EGFP) |
|
| 1 | Goode et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-90N12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126437 (1) | 4981 nt | ||
| Genomic | GenBank:CR376723 (1) | 213541 nt | ||
| Polypeptide | UniProtKB:B0UXI4 (1) | 670 aa |
- Gabellini, C., Pucci, C., De Cesari, C., Martini, D., Di Lauro, C., Digregorio, M., Norton, W., Zippo, A., Sessa, A., Broccoli, V., Andreazzoli, M. (2022) CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Griffin, A., Carpenter, C., Liu, J., Paterno, R., Grone, B., Hamling, K., Moog, M., Dinday, M.T., Figueroa, F., Anvar, M., Ononuju, C., Qu, T., Baraban, S.C. (2021) Phenotypic analysis of catastrophic childhood epilepsy genes. Communications biology. 4:680
- Goode, C., Voeun, M., Ncube, D., Eisen, J., Washbourne, P., Tallafuss, A. (2020) Late onset of Synaptotagmin 2a expression at synapses relevant to social behavior. The Journal of comparative neurology. 529(9):2176-2188
- Xue, C., Wang, H.H., Zhu, J., Zhou, J. (2018) The expression patterns of vestigial like family member 4 genes in zebrafish embryogenesis. Gene expression patterns : GEP. 28:34-41
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cheng, Y., Ekker, M., Chan, H.M. (2015) Relative developmental toxicities of pentachloroanisole and pentachlorophenol in a zebrafish model (Danio rerio). Ecotoxicology and environmental safety. 112C:7-14
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Garbarino, G., Costa, S., Pestarino, M., Candiani, S. (2014) Differential expression of synapsin genes during early zebrafish development. Neuroscience. 280:351-67
- Rodriguez, R.S., Haugen, R., Rueber, A., Huang, C.C. (2014) Reversible neuronal and muscular toxicity of caffeine in developing vertebrates. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 163:47-54
- Easley-Neal, C., Fierro, J., Buchanan, J., and Washbourne, P. (2013) Late Recruitment of Synapsin to Nascent Synapses Is Regulated by Cdk5. Cell Reports. 3(4):1199-1212
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