Gene

iqsec2b

ID

ZDB-GENE-081105-73

Name

IQ motif and Sec7 domain ArfGEF 2b

Symbol

iqsec2b Nomenclature History

Previous Names

iqsec2
si:ch211-218o21.3

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have ARF guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With iqsec2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
non-syndromic X-linked intellectual disability 1	Alliance	Intellectual developmental disorder, X-linked 1	309530

Associated With iqsec2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR000904	Sec7 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR033742	IQ motif and SEC7 domain-containing protein, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR023394	Sec7, C-terminal domain superfamily
Homologous_superfamily	IPR035999	Sec7 domain superfamily

Domain Details Per Protein

Protein	Length	IQ motif and SEC7 domain-containing protein, PH domain	IQ motif, EF-hand binding site	PH-like domain superfamily	Pleckstrin homology domain	Sec7, C-terminal domain superfamily	Sec7 domain	Sec7 domain superfamily
UniProtKB:A0A8M1PUK2 InterPro	1527
UniProtKB:A0A8M3BBZ0 InterPro	1435
UniProtKB:A0A8M2BFA4 InterPro	1095
UniProtKB:E9QDV4 InterPro	1520
UniProtKB:A0A8M9PRI2 InterPro	1574
UniProtKB:A0A8M2BEM6 InterPro	1581
UniProtKB:A0A8M2BEK2 InterPro	1101

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	iqsec2b-202 (1) Ensembl	Havana	4120 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations