Gene
rev1
- ID
- ZDB-GENE-081105-180
- Name
- REV1 DNA directed polymerase
- Symbol
- rev1 Nomenclature History
- Previous Names
-
- si:dkey-57a22.7
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables G-quadruplex DNA binding activity. Predicted to be involved in error-free translesion synthesis and error-prone translesion synthesis. Predicted to act upstream of or within DNA biosynthetic process and DNA repair. Predicted to be located in nucleus. Orthologous to human REV1 (REV1 DNA directed polymerase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chen et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rev1 | Zhao et al., 2020 | |
| MO1-rev1 | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR025527 | HUWE1/REV1, ubiquitin-binding motif |
| Conserved_site | IPR047346 | DNA repair protein REV1, ubiquitin-binding motif 1/2 |
| Domain | IPR001126 | UmuC domain |
| Domain | IPR001357 | BRCT domain |
| Domain | IPR017961 | DNA polymerase, Y-family, little finger domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | BRCT domain | BRCT domain superfamily | DNA polymerase IV/DNA polymerase iota-like, thumb domain | DNA polymerase, Y-family, little finger domain | DNA polymerase, Y-family, little finger domain superfamily | DNA repair protein Rev1 | DNA repair protein Rev1, C-terminal | DNA repair protein REV1, ubiquitin-binding motif 1/2 | DNA/RNA polymerase superfamily | HUWE1/REV1, ubiquitin-binding motif | Rev1, C-terminal domain superfamily | Reverse transcriptase/Diguanylate cyclase domain | UmuC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z8G9 | InterPro | 1201 | |||||||||||||
| UniProtKB:A0A8M3AVZ1 | InterPro | 1261 | |||||||||||||
| UniProtKB:A0A8M2BF27 | InterPro | 1262 | |||||||||||||
| UniProtKB:B0UY97 | InterPro | 1268 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-57A22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-58D5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123300 (1) | |||
| Genomic | GenBank:CR536604 (1) | 217381 nt | ||
| Polypeptide | UniProtKB:B0UY97 (1) | 1268 aa |
- Ketkar, A., Sewilam, R.S., McCrury, M.J., Hall, J.S., Bell, A., Paxton, B.C., Tripathi, S., Gunderson, J.E.C., Eoff, R.L. (2023) Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis. RSC chemical biology. 4:466485466-485
- Chen, B., Zheng, Y.M., Zhang, M.Q., Han, Y., Zhang, J.P., Hu, C.Q. (2020) Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model. Frontiers in pharmacology. 10:1504
- Zhao, X., Lorent, K., Escobar-Zarate, D., Rajagopalan, R., Loomes, K.M., Gillespie, K., Mesaros, C., Estrada, M.A., Blair, I., Winkler, J.D., Spinner, N.B., Devoto, M., Pack, M. (2020) Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia. Gastroenterology. 159(3):1068-1084.e2
- Murphy, P.J., Wu, S.F., James, C.R., Wike, C.L., Cairns, B.R. (2018) Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming. Cell. 172(5):993-1006.e13
- Emerson, S.E., St Clair, R.M., Waldron, A.L., Bruno, S.R., Duong, A., Driscoll, H.E., Ballif, B.A., McFarlane, S., Ebert, A.M. (2017) Identification of target genes downstream of Semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(7):539-549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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