Gene
pde4d
- ID
- ZDB-GENE-081105-16
- Name
- phosphodiesterase 4D, cAMP-specific
- Symbol
- pde4d Nomenclature History
- Previous Names
-
- si:dkey-190g11.2
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to act upstream of or within signal transduction. Is expressed in brain; female organism; and head. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrodysostosis | Alliance | Acrodysostosis 2, with or without hormone resistance | 614613 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
| Domain | IPR002073 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Domain | IPR003607 | HD/PDEase domain |
| Domain | IPR040844 | Phosphodiesterase 4 upstream conserved regions (UCR) |
| Family | IPR023088 | 3'5'-cyclic nucleotide phosphodiesterase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | 3'5'-cyclic nucleotide phosphodiesterase | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | HD/PDEase domain | Phosphodiesterase 4 upstream conserved regions (UCR) |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q3T2 | InterPro | 703 | ||||||
| UniProtKB:A0A8M3B1W5 | InterPro | 769 | ||||||
| UniProtKB:A0A8M3B4T1 | InterPro | 726 | ||||||
| UniProtKB:A0A8M9PF62 | InterPro | 92 | ||||||
| UniProtKB:A0AB32THJ6 | InterPro | 797 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available