Gene
si:ch211-45c16.2
- ID
- ZDB-GENE-081105-15
- Name
- si:ch211-45c16.2
- Symbol
- si:ch211-45c16.2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in JNK cascade and stress-activated MAPK cascade. Predicted to act upstream of or within protein autophosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human MAP3K13 (mitogen-activated protein kinase kinase kinase 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Adula et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la232 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa13451 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13481 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13787 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15617 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17143 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34779 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44715 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-si:ch211-45c16.2 | Adula et al., 2022 | |
| CRISPR2-si:ch211-45c16.2 | Adula et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Family | IPR017419 | Mitogen-activated protein kinase kinase kinase 12/13 |
| Family | IPR051681 | Serine/Threonine Kinases and Pseudokinases |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Mitogen-activated protein kinase kinase kinase 12/13 | Protein kinase domain | Protein kinase-like domain superfamily | Serine/Threonine Kinases and Pseudokinases | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7UVK5 | InterPro | 981 | ||||||
| UniProtKB:A0A8M9QKF0 | InterPro | 858 | ||||||
| UniProtKB:A0A8M6Z2U3 | InterPro | 982 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map3k13-201
(1)
|
Ensembl | 3,296 nt | ||
| mRNA |
map3k13-202
(1)
|
Ensembl | 3,246 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-45C16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_691738 (1) | 3301 nt | ||
| Genomic | GenBank:CR753902 (1) | 158229 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z2U3 (1) | 982 aa |
No data available