Gene
htr2cl1
- ID
- ZDB-GENE-081104-48
- Name
- 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1
- Symbol
- htr2cl1 Nomenclature History
- Previous Names
-
- si:dkey-24g18.2
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; release of sequestered calcium ion into cytosol; and serotonin receptor signaling pathway. Predicted to be active in dendrite and plasma membrane. Is expressed in integument; nervous system; ovary; and skeletal muscle. Human ortholog(s) of this gene implicated in bipolar disorder; obesity; and schizophrenia. Orthologous to human HTR2C (5-hydroxytryptamine receptor 2C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa13537 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 5-hydroxytryptamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:F6PDA4 | InterPro | 518 | |||
| UniProtKB:B2WSB2 | InterPro | 518 | |||
| UniProtKB:A0AB32TLT9 | InterPro | 109 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
htr2cl1-201
(1)
|
Ensembl | 3,146 nt | ||
| mRNA |
htr2cl1-202
(1)
|
Ensembl | 3,916 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-151K15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-24G18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001129893 (1) | 3161 nt | ||
| Genomic | GenBank:BX296521 (1) | 185817 nt | ||
| Polypeptide | UniProtKB:B2WSB2 (1) | 518 aa |
No data available
- Gonçalves, C., Kareklas, K., Teles, M.C., Varela, S.A.M., Costa, J., Leite, R.B., Paixão, T., Oliveira, R.F. (2022) Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Genes, brain, and behavior. 21(5):e12809
- Horzmann, K.A., Lin, L.F., Taslakjian, B., Yuan, C., Freeman, J.L. (2022) Anxiety-related behavior and associated brain transcriptome and epigenome alterations in adult female zebrafish exposed to atrazine during embryogenesis. Chemosphere. 308(Pt 3):136431
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Shi, Z., Liang, X., Zhao, Y., Liu, W., Martyniuk, C.J. (2022) Neurotoxic effects of synthetic phenolic antioxidants on dopaminergic, serotoninergic, and GABAergic signaling in larval zebrafish (Danio rerio). The Science of the total environment. 830:154688
- do Carmo Silva, R.X., do Nascimento, B.G., Gomes, G.C.V., da Silva, N.A.H., Pinheiro, J.S., da Silva Chaves, S.N., Pimentel, A.F.N., Costa, B.P.D., Herculano, A.M., Lima-Maximino, M., Maximino, C. (2021) 5-HT2C agonists and antagonists block different components of behavioral responses to potential, distal, and proximal threat in zebrafish. Pharmacology, biochemistry, and behavior. 210:173276
- Yang, H., Liang, X., Zhao, Y., Gu, X., Mao, Z., Zeng, Q., Chen, H., Martyniuk, C.J. (2021) Molecular and behavioral responses of zebrafish embryos/larvae after sertraline exposure. Ecotoxicology and environmental safety. 208:111700
- Attaran, A., Salahinejad, A., Naderi, M., Crane, A.L., Niyogi, S., Chivers, D.P. (2020) Effects of chronic exposure to selenomethionine on social learning outcomes in zebrafish (Danio rerio): serotonergic dysregulation and oxidative stress in the brain. Chemosphere. 247:125898
- García-González, J., Brock, A.J., Parker, M.O., Riley, R.J., Joliffe, D., Sudwarts, A., Teh, M.T., Busch-Nentwich, E.M., Stemple, D.L., Martineau, A.R., Kaprio, J., Palviainen, T., Kuan, V., Walton, R.T., Brennan, C.H. (2020) Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. eLIFE. 9:
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
- Cunha, V., Rodrigues, P., Santos, M.M., Moradas-Ferreira, P., Ferreira, M. (2017) Fluoxetine modulates the transcription of genes involved in serotonin, dopamine and adrenergic signalling in zebrafish embryos. Chemosphere. 191:954-961
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