Gene
adcy5
- ID
- ZDB-GENE-081104-470
- Name
- adenylate cyclase 5
- Symbol
- adcy5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable adenylate cyclase activity. Acts upstream of or within melanosome localization; regulation of protein phosphorylation; and response to ethanol. Predicted to be located in cilium and membrane. Predicted to be active in plasma membrane. Is expressed in brain; head; and heart. Orthologous to human ADCY5 (adenylate cyclase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-adcy5 | Zhang et al., 2022 | |
| MO1-adcy5 | N/A | O'Hare et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018297 | Adenylyl cyclase class-4/guanylyl cyclase, conserved site |
| Domain | IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| Domain | IPR009398 | Adenylate cyclase, conserved domain |
| Domain | IPR032628 | Adenylate cyclase, N-terminal |
| Family | IPR030672 | Adenylate cyclase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Adenylate cyclase | Adenylate cyclase, conserved domain | Adenylate cyclase, N-terminal | Adenylyl cyclase class-3/4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | Nucleotide cyclase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:D2CFN3 | InterPro | 1186 | ||||||
| UniProtKB:A0AB32TY21 | InterPro | 1191 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-92C19 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-60A7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001171585 (1) | 8199 nt | ||
| Genomic | GenBank:CU896658 (1) | 173880 nt | ||
| Polypeptide | UniProtKB:A0AB32TY21 (1) | 1191 aa |
- Vacca, F., Gomes, A.S., Murashita, K., Cinquetti, R., Roseti, C., Barca, A., Rønnestad, I., Verri, T., Bossi, E. (2022) Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters. The Journal of physiology. 600(10):2377-2400
- Zhang, L., Wan, M., Tohti, R., Jin, D., Zhong, T.P. (2022) Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation. International Journal of Molecular Sciences. 23(22):
- Liang, Y.Q., Jing, Z., Pan, C.G., Lin, Z., Zhen, Z., Hou, L., Dong, Z. (2020) The progestin norethindrone alters growth, reproductive histology and gene expression in zebrafish (Danio rerio). Chemosphere. 242:125285
- Shi, W.J., Hu, L.X., Huang, G.Y., Liu, Y.S., Zhang, J.N., Xie, L., Ying, G.G. (2018) Dydrogesterone affects the transcription of genes in GnRH and steroidogenesis pathways and increases the frequency of atretic follicles in zebrafish (Danio rerio). Chemosphere. 216:725-732
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Shi, W.J., Ying, G.G., Huang, G.Y., Liang, Y.Q., Hu, L.X., Zhao, J.L., Zhang, J.N. (2017) Transcriptional and Biochemical Alterations in Zebrafish Eleuthero-Embryos (Danio rerio) After Exposure to Synthetic Progestogen Dydrogesterone. Bulletin of environmental contamination and toxicology. 99(1):39-45
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wagle, M., Mathur, P., and Guo, S. (2011) Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(1):214-224
- Peng, J., Wagle, M., Mueller, T., Mathur, P., Lockwood, B.L., Bretaud, S., and Guo, S. (2009) Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(26):8408-8418
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