Gene
fap
- ID
- ZDB-GENE-081104-439
- Name
- fibroblast activation protein, alpha
- Symbol
- fap Nomenclature History
- Previous Names
-
- si:dkey-81j5.3
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable dipeptidyl-peptidase activity. Acts upstream of or within bone mineralization and negative regulation of bone mineralization. Predicted to be located in lamellipodium membrane. Predicted to be active in plasma membrane. Is expressed in neurocranium. Orthologous to human FAP (fibroblast activation protein alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wei et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Wei et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fap | Wei et al., 2020 | |
| CRISPR2-fap | Wei et al., 2020 | |
| MO1-fap | N/A | Wei et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR002471 | Peptidase S9, serine active site |
| Domain | IPR001375 | Peptidase S9, prolyl oligopeptidase, catalytic domain |
| Domain | IPR002469 | Dipeptidylpeptidase IV, N-terminal domain |
| Domain | IPR040522 | Dipeptidyl peptidase 4, low complexity region |
| Family | IPR050278 | Serine protease S9B/DPPIV |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | Dipeptidyl peptidase 4, low complexity region | Dipeptidylpeptidase IV, N-terminal domain | Peptidase S9, prolyl oligopeptidase, catalytic domain | Peptidase S9, serine active site | Serine protease S9B/DPPIV |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0R1C4 | InterPro | 750 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-81J5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001920799 (1) | |||
| Genomic | GenBank:AL954669 (1) | 133954 nt | ||
| Polypeptide | UniProtKB:B0R1C4 (1) | 750 aa |
- Dong, Z., Li, Y., Chen, X., Lai, X., Liu, M. (2020) A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 251:110522
- Wei, H., Xu, Y., Wang, Y., Xu, L., Mo, C., Li, L., Shen, B., Sun, Y., Cheng, P., Yang, L., Pang, Y., Qin, A., Cao, Y., Morrison, S.J., Yue, R. (2020) Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target. Cell Reports. 33:108252
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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