Gene

fap

ID
ZDB-GENE-081104-439
Name
fibroblast activation protein, alpha
Symbol
fap Nomenclature History
Previous Names
  • si:dkey-81j5.3
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including DPP4 (dipeptidyl peptidase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Wei et al., 2020
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Wei et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fap Human Ortholog
No data available
Associated With fap Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR002471 Peptidase S9, serine active site
Domain IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
Domain IPR002469 Dipeptidylpeptidase IV, N-terminal domain
Domain IPR040522 Dipeptidyl peptidase 4, low complexity region
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Domain Details Per Protein
Protein Length Alpha/Beta hydrolase fold Dipeptidyl peptidase 4, low complexity region Dipeptidylpeptidase IV, N-terminal domain Peptidase S9, prolyl oligopeptidase, catalytic domain Peptidase S9, serine active site
UniProtKB:B0R1C4 750
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA fap-201 (1) Havana 2927 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations