Gene
foxp3b
- ID
- ZDB-GENE-081104-332
- Name
- forkhead box P3b
- Symbol
- foxp3b Nomenclature History
- Previous Names
-
- si:dkey-16n15.5 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in head kidney and testis. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome | Alliance | Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked | 304790 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Domain | IPR032354 | FOXP, coiled-coil domain |
| Domain | IPR047413 | Forkhead box protein P3, forkhead domain |
| Family | IPR050998 | Forkhead box protein P |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box protein P | Forkhead box protein P3, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXP, coiled-coil domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32U0M9 | InterPro | 394 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxp3b-201
(1)
|
Ensembl | 2,051 nt | ||
| mRNA |
foxp3b-202
(1)
|
Ensembl | 1,131 nt | ||
| mRNA |
foxp3b-203
(1)
|
Ensembl | 2,139 nt |
Interactions and Pathways
No data available
Plasmids
No data available