Gene
pcdh7b
- ID
- ZDB-GENE-081104-299
- Name
- protocadherin 7b
- Symbol
- pcdh7b Nomenclature History
- Previous Names
-
- sb:eu592
- si:dkey-104n16.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell adhesion. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including epidermis; nervous system; neural plate; otic vesicle; and periderm. Orthologous to human PCDH7 (protocadherin 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu592 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pcdh7b | Xiao et al., 2023 | |
| MO1-pcdh7b | N/A | Xiao et al., 2023 |
| MO2-pcdh7b | N/A | Xiao et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Cadherin, N-terminal | Protocadherin | Protocadherin/Cadherin-related Cell Adhesion |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:X1WEN8 | InterPro | 1043 | ||||||
| UniProtKB:A0A8M9QD52 | InterPro | 1106 | ||||||
| UniProtKB:A0A0H2UKU4 | InterPro | 1242 | ||||||
| UniProtKB:A0A8M9QI41 | InterPro | 1234 | ||||||
| UniProtKB:A0A8M9PQ84 | InterPro | 1036 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcdh7b-201
(1)
|
Ensembl | 3,304 nt | ||
| mRNA |
pcdh7b-202
(1)
|
Ensembl | 4,683 nt | ||
| mRNA |
pcdh7b-203
(1)
|
Ensembl | 3,729 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-104N16 | ZFIN Curated Data | |
| Encodes | EST | eu592 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001365653 (1) | |||
| Genomic | GenBank:CR318596 (1) | 225081 nt | ||
| Polypeptide | UniProtKB:A0A0H2UKU4 (1) | 1242 aa |
- Ezhkova, D., Schwarzer, S., Spieß, S., Geffarth, M., Machate, A., Zöller, D., Stucke, J., Alexopoulou, D., Lesche, M., Dahl, A., Hans, S. (2023) Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Biology Open. 12(6):
- Xiao, Y., Hu, M., Lin, Q., Zhang, T., Li, S., Shu, L., Song, X., Xu, X., Meng, W., Li, X., Xu, H., Mo, X. (2023) Dopey2 and Pcdh7 orchestrate the development of embryonic neural stem cells/ progenitors in zebrafish. iScience. 26:106273106273
- Tuschl, K., White, R.J., Trivedi, C., Valdivia, L.E., Niklaus, S., Bianco, I.H., Dadswell, C., González-Méndez, R., Sealy, I.M., Neuhauss, S.C.F., Houart, C., Rihel, J., Wilson, S.W., Busch-Nentwich, E.M. (2022) Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish. Disease models & mechanisms. 15(6)
- Lüffe, T.M., D'Orazio, A., Bauer, M., Gioga, Z., Schoeffler, V., Lesch, K.P., Romanos, M., Drepper, C., Lillesaar, C. (2021) Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders. Translational psychiatry. 11:529
- Pandey, S., Shekhar, K., Regev, A., Schier, A.F. (2018) Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq. Current biology : CB. 28(7):1052-1065.e7
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Kimelman, D., Smith, N.L., Lai, J.K.H., Stainier, D.Y. (2017) Regulation of posterior body and epidermal morphogenesis in Zebrafish by localized Yap1 and Wwtr1. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M., Nissim, S., Goessling, W., North, T.E. (2015) Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem cells (Dayton, Ohio). 33(8):2596-612
- Hogl, S., van Bebber, F., Dislich, B., Kuhn, P.H., Haass, C., Schmid, B., and Lichtenthaler, S.F. (2013) Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 13(9):1519-27
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