ZFIN is now using GRCz12tu for Genomic Data
Gene
rnf220b
- ID
- ZDB-GENE-081104-195
- Name
- ring finger protein 220b
- Symbol
- rnf220b Nomenclature History
- Previous Names
-
- si:ch211-241d21.7
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypomyelinating leukodystrophy 23 | Alliance | Leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy | 619688 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR031824 | E3 ubiquitin-protein ligase RNF220, middle domain |
| Domain | IPR040178 | E3 ubiquitin-protein ligase RNF220, RING finger |
| Family | IPR052443 | E3 ubiquitin-protein ligase RNF220-like |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase RNF220-like | E3 ubiquitin-protein ligase RNF220, middle domain | E3 ubiquitin-protein ligase RNF220, RING finger | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7TAR9 | InterPro | 588 | |||||
| UniProtKB:A0AC58G975 | InterPro | 656 | |||||
| UniProtKB:A0AC58G980 | InterPro | 684 | |||||
| UniProtKB:A0AC58G982 | InterPro | 656 | |||||
| UniProtKB:A0AC58G985 | InterPro | 649 | |||||
| UniProtKB:A0AC58G990 | InterPro | 621 | |||||
| UniProtKB:A0AC58G991 | InterPro | 621 | |||||
| UniProtKB:A0AC58G998 | InterPro | 656 | |||||
| UniProtKB:A0A8M6Z2A0 | InterPro | 553 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rnf220-203
(1)
|
Ensembl | 1,903 nt | ||
| mRNA |
rnf220b-201
(1)
|
Ensembl | 1,108 nt | ||
| mRNA |
rnf220b-202
(1)
|
Ensembl | 3,450 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers