Gene
mutyh
- ID
- ZDB-GENE-081104-193
- Name
- mutY DNA glycosylase
- Symbol
- mutyh Nomenclature History
- Previous Names
-
- si:ch211-241d21.4
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Human ortholog(s) of this gene implicated in familial adenomatous polyposis; familial adenomatous polyposis 2; and stomach carcinoma. Orthologous to human MUTYH (mutY DNA glycosylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial adenomatous polyposis 2 | Alliance | Adenomas, multiple colorectal | 608456 |
| stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR004036 | Endonuclease III-like, conserved site-2 |
| Domain | IPR003265 | HhH-GPD domain |
| Domain | IPR029119 | Adenine DNA glycosylase, C-terminal |
| Family | IPR044298 | Adenine/Thymine-DNA glycosylase |
| Homologous_superfamily | IPR011257 | DNA glycosylase |
| Homologous_superfamily | IPR015797 | NUDIX hydrolase-like domain superfamily |
| Homologous_superfamily | IPR023170 | Helix-hairpin-helix, base-excision DNA repair, C-terminal |
Domain Details Per Protein
| Protein | Length | Adenine DNA glycosylase, C-terminal | Adenine/Thymine-DNA glycosylase | DNA glycosylase | Endonuclease III-like, conserved site-2 | Helix-hairpin-helix, base-excision DNA repair, C-terminal | HhH-GPD domain | NUDIX hydrolase-like domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8JJK1
|
526 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
ct025742.1-201
(1)
|
Havana | 1827 nt |
Interactions and Pathways
No data available
Plasmids
No data available