Gene
mutyh
- ID
- ZDB-GENE-081104-193
- Name
- mutY DNA glycosylase
- Symbol
- mutyh Nomenclature History
- Previous Names
-
- si:ch211-241d21.4
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA N-glycosylase activity and DNA binding activity. Predicted to be involved in base-excision repair and mismatch repair. Predicted to act upstream of or within DNA repair. Predicted to be located in mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis; familial adenomatous polyposis 2; stomach cancer; and stomach carcinoma. Orthologous to human MUTYH (mutY DNA glycosylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial adenomatous polyposis 2 | Alliance | Adenomas, multiple colorectal | 608456 |
| stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR004036 | Endonuclease III-like, conserved site-2 |
| Domain | IPR003265 | HhH-GPD domain |
| Domain | IPR029119 | Adenine DNA glycosylase, C-terminal |
| Family | IPR041090 | Protein of unknown function DUF5578 |
| Family | IPR044298 | Adenine/Thymine-DNA glycosylase |
| Homologous_superfamily | IPR011257 | DNA glycosylase |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR015797 | NUDIX hydrolase-like domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR023170 | Helix-hairpin-helix, base-excision DNA repair, C-terminal |
Domain Details Per Protein
| Protein | Additional Resources | Length | Adenine DNA glycosylase, C-terminal | Adenine/Thymine-DNA glycosylase | Armadillo-like helical | Armadillo-type fold | DNA glycosylase | Endonuclease III-like, conserved site-2 | Helix-hairpin-helix, base-excision DNA repair, C-terminal | HhH-GPD domain | NUDIX hydrolase-like domain superfamily | Protein of unknown function DUF5578 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8JJK1 | InterPro | 526 | ||||||||||
| UniProtKB:A0AB32U1S6 | InterPro | 862 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ct025742.1-201
(1)
|
Ensembl | 1,827 nt |
Interactions and Pathways
No data available
Plasmids
No data available