Gene
plat
- ID
- ZDB-GENE-081104-181
- Name
- plasminogen activator, tissue
- Symbol
- plat Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in plasminogen activation and smooth muscle cell migration. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in ovarian follicle. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; hemophilia (multiple); osteonecrosis; and type 2 diabetes mellitus. Orthologous to human PLAT (plasminogen activator, tissue type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17358 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000742 | EGF-like domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine Proteases (Peptidase S1 Family) | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site | Tissue plasminogen activator |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PR58 | InterPro | 577 | |||||||||||||
| UniProtKB:F1QB78 | InterPro | 578 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-220D9 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-117B11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002663051 (1) | |||
| Genomic | GenBank:AL954172 (1) | 201525 nt | ||
| Polypeptide | UniProtKB:F1QB78 (1) | 578 aa |
- Zhang, A.N., Huang, C., Yan, L., Liu, X., Wang, F., Zhang, Z., Li, L., Zhang, C., Zhang, Q. (2023) Metabolic regulation and antihyperglycemic properties of diet-derived PGG through transcriptomic and metabolomic profiling. Food & function. 14(12):5620-5630
- Han, S., Fei, F., Sun, S., Zhang, D., Dong, Q., Wang, X., Wang, L. (2020) Increased anxiety was found in serpini1 knockout zebrafish larval. Biochemical and Biophysical Research Communications. 534:1013-1019
- Li, J., Niu, C., Cheng, C.H.K. (2018) Igf3 serves as a mediator of LH in zebrafish ovulation. Biology of reproduction. 99(6):1235-1243
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Azuaje, F.J. (2014) Selecting biologically informative genes in co-expression networks with a centrality score. Biology Direct. 9:12
- Chu, L., Li, J., Liu, Y., Hu, W., Cheng, C.H. (2014) Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction. Molecular endocrinology (Baltimore, Md.). 28(11):1785-95
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