Gene
fhod3b
- ID
- ZDB-GENE-081028-61
- Name
- formin homology 2 domain containing 3b
- Symbol
- fhod3b Nomenclature History
- Previous Names
-
- si:ch211-209d1.1
- zgc:103746
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of stress fiber assembly. Predicted to be active in cytoplasm and cytoskeleton. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human FHOD3 (formin homology 2 domain containing 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cardiomyopathy, familial hypertrophic, 28 | 619402 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR014768 | Rho GTPase-binding/formin homology 3 (GBD/FH3) domain |
| Domain | IPR015425 | Formin, FH2 domain |
| Domain | IPR041387 | FHOD1, N-terminal GTPase-binding domain |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR042201 | Formin, FH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | FHOD1, N-terminal GTPase-binding domain | Formin, FH2 domain | Formin, FH2 domain superfamily | Rho GTPase-binding/formin homology 3 (GBD/FH3) domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PDK4 | InterPro | 1516 | ||||||
| UniProtKB:A0A8M9PK03 | InterPro | 1692 | ||||||
| UniProtKB:A0A8M9PC43 | InterPro | 147 | ||||||
| UniProtKB:A0A8M9P8A0 | InterPro | 1532 | ||||||
| UniProtKB:A0A8M9PNP0 | InterPro | 133 | ||||||
| UniProtKB:A0A8M9NZN4 | InterPro | 1557 | ||||||
| UniProtKB:A0AB32T566 | InterPro | 1684 | ||||||
| UniProtKB:A0AB32TA77 | InterPro | 1541 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fhod3b-201
(1)
|
Ensembl | 2,542 nt | ||
| mRNA |
fhod3b-203
(1)
|
Ensembl | 959 nt | ||
| mRNA |
fhod3b-204
(1)
|
Ensembl | 1,261 nt | ||
| mRNA |
fhod3b-205
(1)
|
Ensembl | 363 nt | ||
| ncRNA |
fhod3b-003
(1)
|
Ensembl | 917 nt |
Interactions and Pathways
No data available
Plasmids
No data available