Gene

tbxtb

ID
ZDB-GENE-081028-48
Name
T-box transcription factor Tb
Symbol
tbxtb Nomenclature History
Previous Names
  • bra (1)
  • tb
  • brachyury (1)
  • no tail b
  • ntlb
  • si:ch211-130h14.5
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including mesoderm formation; regulation of transcription by RNA polymerase II; and somitogenesis. Acts upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in margin; mesoderm; notochord; tail bud; and ventral mesoderm. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Martin et al., 2008
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbxtb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Sacral agenesis with vertebral anomalies 615709
{Neural tube defects, susceptibility to} 182940
Associated With tbxtb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Family IPR001699 Transcription factor, T-box
Family IPR002070 Transcription factor, Brachyury
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR036960 T-box superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding T-box superfamily Transcription factor, Brachyury Transcription factor, T-box Transcription factor, T-box, conserved site
UniProtKB:X1WGE3 424
UniProtKB:A0A2R8QB37 427
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations