Gene
gng13a
- ID
- ZDB-GENE-081022-188
- Name
- guanine nucleotide binding protein (G protein), gamma 13a
- Symbol
- gng13a Nomenclature History
- Previous Names
-
- gng13
- gng14 (1)
- zgc:195149
- zgc:195164
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNG13 (G protein subunit gamma 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zko188a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gng13a | (2) | |
| CRISPR2-gng13a | (2) | |
| CRISPR3-gng13a | (2) | |
| CRISPR4-gng13a | (2) | |
| CRISPR5-gng13a | (2) | |
| CRISPR6-gng13a | (2) | |
| CRISPR7-gng13a | (2) | |
| CRISPR8-gng13a | (2) | |
| CRISPR9-gng13a | (2) | |
| CRISPR10-gng13a | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | G-protein gamma-like domain | G-protein gamma-like domain superfamily | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 |
|---|---|---|---|---|---|
| UniProtKB:B3DIM4 | InterPro | 67 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gng13a-201
(1)
|
Ensembl | 515 nt | ||
| mRNA |
gng13a-202
(1)
|
Ensembl | 573 nt | ||
| mRNA |
gng13a-203
(1)
|
Ensembl | 284 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gng13a:EGFP) |
|
| 1 | Castranova et al., 2025 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-57D7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195149 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195164 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001166125 (1) | 574 nt | ||
| Genomic | GenBank:BX901912 (1) | 140289 nt | ||
| Polypeptide | UniProtKB:B3DIM4 (1) | 67 aa |
- Castranova, D., Kenton, M.I., Kraus, A., Dell, C.W., Park, J.S., Venero Galanternik, M., Park, G., Lumbantobing, D.N., Dye, L., Marvel, M., Iben, J., Taimatsu, K., Pham, V., Willms, R.J., Blevens, L., Robertson, T.F., Hou, Y., Huttenlocher, A., Foley, E., Parenti, L.R., Frazer, J.K., Narayan, K., Weinstein, B.M. (2025) The axillary lymphoid organ is an external, experimentally accessible immune organ in the zebrafish. The Journal of experimental medicine. 222:
- Zhu, H., Zhang, X., Xu, S., Wu, J., Hou, M., Zhao, H., Zhou, Q., Zhong, X. (2022) Gene duplication, conservation, and divergence of activating transcription factor 5 gene in zebrafish. Journal of experimental zoology. Part B, Molecular and developmental evolution. 338(5):301-313
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Ferreira, T., Wilson, S.R., Choi, Y.G., Risso, D., Dudoit, S., Speed, T.P., Ngai, J. (2014) Silencing of Odorant Receptor Genes by G Protein βγ Signaling Ensures the Expression of One Odorant Receptor per Olfactory Sensory Neuron. Neuron. 81(4):847-59
- Mulligan, T., Blaser, H., Raz, E., and Farber, S.A. (2010) Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish. Cellular Signalling. 22(2):221-233
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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