Gene
pbrm1
- ID
- ZDB-GENE-080926-4
- Name
- polybromo 1
- Symbol
- pbrm1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity. Predicted to be involved in chromatin remodeling and transcription elongation by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be part of RSC-type complex and SWI/SNF complex. Is expressed in somite. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Armant et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa970 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa17189 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa27716 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa31811 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa31812 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa35009 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa41765 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 7 of 7
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
nonpapillary renal cell carcinoma | Alliance | ?Renal cell carcinoma, clear cell | 144700 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Bromo adjacent homology (BAH) domain | Bromo adjacent homology (BAH) domain superfamily | Bromodomain | Bromodomain, conserved site | Bromodomain-like superfamily | High mobility group box domain | High mobility group box domain superfamily | Protein polybromo-1, Bromodomain 5 | Remodelling complex subunit Rsc/polybromo |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:E7F8D8 | InterPro | 1627 | |||||||||
UniProtKB:A0A8M3B6P7 | InterPro | 1559 | |||||||||
UniProtKB:A0A8M9QLS6 | InterPro | 1582 | |||||||||
UniProtKB:A0AB32TZU7 | InterPro | 1604 |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-80B12 | ZFIN Curated Data | |
Contained in | Fosmid | ZFOS-302B3 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_009305787 (1) | 5443 nt | ||
Genomic | GenBank:CR450797 (1) | 101488 nt | ||
Polypeptide | UniProtKB:E7F8D8 (1) | 1627 aa |
- Comparative Orthology
- Alliance
- Peña, O.A., Lubin, A., Rowell, J., Hoade, Y., Khokhar, N., Lemmik, H., Mahony, C., Dace, P., Umamahesan, C., Payne, E.M. (2021) Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish. Frontiers in cell and developmental biology. 9:708113
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Xiao, C., Gao, L., Hou, Y., Xu, C., Chang, N., Wang, F., Hu, K., He, A., Luo, Y., Wang, J., Peng, J., Tang, F., Zhu, X., Xiong, J.W. (2016) Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish. Nature communications. 7:13787
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Armant, O., März, M., Schmidt, R., Ferg, M., Diotel, N., Ertzer, R., Bryne, J.C., Yang, L., Baader, I., Reischl, M., Legradi, J., Mikut, R., Stemple, D., Ijcken, W.V., van der Sloot, A., Lenhard, B., Strähle, U., and Rastegar, S. (2013) Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Developmental Biology. 380(2):351-62
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
1 - 6 of 6
Show