Gene

pbrm1

ID
ZDB-GENE-080926-4
Name
polybromo 1
Symbol
pbrm1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable chromatin binding activity. Predicted to be involved in chromatin remodeling and transcription elongation by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be part of RSC-type complex and SWI/SNF complex. Is expressed in somite. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Armant et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa970Allele with one point mutationUnknownPremature StopENU
sa17189Allele with one point mutationUnknownSplice SiteENU
sa27716Allele with one point mutationUnknownPremature StopENU
sa31811Allele with one point mutationUnknownSplice SiteENU
sa31812Allele with one point mutationUnknownSplice SiteENU
sa35009Allele with one point mutationUnknownPremature StopENU
sa41765Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-pbrm1N/AHuang et al., 2013
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Human Disease
Associated With pbrm1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nonpapillary renal cell carcinoma Alliance ?Renal cell carcinoma, clear cell 144700
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Associated With pbrm1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018359 Bromodomain, conserved site
Domain IPR001025 Bromo adjacent homology (BAH) domain
Domain IPR001487 Bromodomain
Domain IPR009071 High mobility group box domain
Domain IPR037968 Protein polybromo-1, Bromodomain 5
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Domain Details Per Protein
Protein Additional Resources Length Bromo adjacent homology (BAH) domain Bromo adjacent homology (BAH) domain superfamily Bromodomain Bromodomain, conserved site Bromodomain-like superfamily High mobility group box domain High mobility group box domain superfamily Protein polybromo-1, Bromodomain 5 Remodelling complex subunit Rsc/polybromo
UniProtKB:E7F8D8 InterPro 1627
UniProtKB:A0A8M3B6P7 InterPro 1559
UniProtKB:A0A8M9QLS6 InterPro 1582
UniProtKB:A0AB32TZU7 InterPro 1604
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 11
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pbrm1-201 (1) Ensembl 5,413 nt
mRNA pbrm1-202 (1) Ensembl 5,756 nt
mRNA pbrm1-203 (1) Ensembl 4,884 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-80B12ZFIN Curated Data
Contained inFosmidZFOS-302B3ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Species Symbol Chromosome Accession # Evidence
HumanPBRM13
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MousePbrm114
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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