Gene
col15a1a
- ID
- ZDB-GENE-080918-1
- Name
- collagen, type XV, alpha 1a
- Symbol
- col15a1a Nomenclature History
- Previous Names
-
- cb605 (1)
- col15a1
- col15a1l
- sb:cb605
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Acts upstream of or within notochord cell differentiation and skeletal muscle tissue development. Predicted to be part of collagen trimer. Is expressed in several structures, including axial mesoderm; central nervous system; chordo neural hinge; integument; and pectoral fin. Orthologous to human COL15A1 (collagen type XV alpha 1 chain).
- Genome Resources
-
- Alliance (1)
- Gene:792366 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) Single Cell Expression Atlas (1) Daniocell (1)
- Thisse Expression Data
-
- cb605 (26 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Pagnon-Minot et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR010515 | Collagenase NC10/endostatin |
Domain | IPR045463 | Collagen type XV/XVIII, trimerization domain |
Domain | IPR048287 | Thrombospondin-like, N-terminal domain |
Family | IPR050149 | Collagen superfamily |
Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Collagenase NC10/endostatin | Collagen superfamily | Collagen triple helix repeat | Collagen type XV/XVIII, trimerization domain | Concanavalin A-like lectin/glucanase domain superfamily | C-type lectin fold | C-type lectin-like/link domain superfamily | Thrombospondin-like, N-terminal domain |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0AB32TKF5 | InterPro | 1164 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Encodes | EST | cb605 | Thisse et al., 2001 | |
Encodes | cDNA | MGC:174956 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001080091 (1) | 3831 nt | ||
Genomic | GenBank:CABZ01080396 (1) | 8427 nt | ||
Polypeptide | UniProtKB:A0AB32TKF5 (1) | 1164 aa |
- Comparative Orthology
- Alliance
- Tlili, S., Yin, J., Rupprecht, J.F., Mendieta-Serrano, M.A., Weissbart, G., Verma, N., Teng, X., Toyama, Y., Prost, J., Saunders, T.E. (2019) Shaping the zebrafish myotome by intertissue friction and active stress. Proceedings of the National Academy of Sciences of the United States of America. 116(51):25430-25439
- Bretaud, S., Nauroy, P., Malbouyres, M., Ruggiero, F. (2018) FISHING FOR COLLAGEN FUNCTION: ABOUT DEVELOPMENT, REGENERATION AND DISEASE. Seminars in cell & developmental biology. 89:100-108
- Petrey, A.C., Flanagan-Steet, H., Johnson, S., Fan, X., De la Rosa, M., Haskins, M.E., Nairn, A.V., Moremen, K.W., and Steet, R. (2012) Excessive activity of cathepsin K is associated with the cartilage defects in a zebrafish model for mucolipidosis II. Disease models & mechanisms. 5(2):177-190
- Warner, C.M., Gust, K.A., Stanley, J.K., Habib, T., Wilbanks, M.S., Garcia-Reyero, N., and Perkins, E.J. (2012) A Systems Toxicology Approach to Elucidate the Mechanisms Involved in RDX Species-Specific Sensitivity. Environmental science & technology. 46(14):7790-7798
- Bretaud, S., Pagnon-Minot, A., Guillon, E., Ruggiero, F., and Le Guellec, D. (2011) Characterization of spatial and temporal expression pattern of Col15a1b during zebrafish development. Gene expression patterns : GEP. 11(1-2):129-134
- Gonzalez-Nunez, V., Nocco, V., and Budd, A. (2010) Characterization of drCol 15a1b: A Novel Component of the Stem Cell Niche in the Zebrafish Retina. Stem cells (Dayton, Ohio). 28(8):1399-1411
- Pagnon-Minot, A., Malbouyres, M., Haftek-Terreau, Z., Kim, H.R., Sasaki, T., Thisse, C., Thisse, B., Ingham, P.W., Ruggiero, F., and Le Guellec, D. (2008) Collagen XV, a novel factor in zebrafish notochord differentiation and muscle development. Developmental Biology. 316(1):21-35
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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